Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder

JM LaSalle - Molecular psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) comprises a heterogeneous group of neurodevelopmental
outcomes in children with a commonality in deficits in social communication and language …

Ten years of EWAS

S Wei, J Tao, J Xu, X Chen, Z Wang, N Zhang… - Advanced …, 2021 - Wiley Online Library
Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation
variation in complex diseases for a decade, and epigenome as a research target has …

Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure

BI Laufer, K Neier, AE Valenzuela, DH Yasui… - Cell reports, 2022 - cell.com
Polychlorinated biphenyls (PCBs) are developmental neurotoxicants implicated as
environmental risk factors for neurodevelopmental disorders (NDDs). Here, we report the …

Placental methylome reveals a 22q13. 33 brain regulatory gene locus associated with autism

Y Zhu, JA Gomez, BI Laufer, CE Mordaunt, JS Mouat… - Genome biology, 2022 - Springer
Background Autism spectrum disorder (ASD) involves complex genetics interacting with the
perinatal environment, complicating the discovery of common genetic risk. The epigenetic …

RUN (X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome

EJ Rozen, CD Ozeroff, MA Allen - Human Genomics, 2023 - Springer
Background RUNX1 is a transcription factor and a master regulator for the specification of
the hematopoietic lineage during embryogenesis and postnatal megakaryopoiesis …

Artificial intelligence for prenatal chromosome analysis

K Boddupally, ER Thuraka - Clinica Chimica Acta, 2024 - Elsevier
This review article delves into the rapidly advancing domain of prenatal diagnostics, with a
primary focus on the detection and management of chromosomal abnormalities such as …

The genetics of neurodevelopment in congenital heart disease

E Patt, A Singhania, AE Roberts, SU Morton - Canadian Journal of …, 2023 - Elsevier
Congenital heart disease (CHD) is the most common birth anomaly, affecting almost 1% of
infants. Neurodevelopmental delay is the most common extracardiac feature in people with …

[HTML][HTML] Long-term effects of wildfire smoke exposure during early life on the nasal epigenome in rhesus macaques

AP Brown, L Cai, BI Laufer, LA Miller, JM LaSalle… - Environment …, 2022 - Elsevier
Background Wildfire smoke is responsible for around 20% of all particulate emissions in the
US and affects millions of people worldwide. Children are especially vulnerable, as ambient …

Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts

JF Dou, LYM Middleton, Y Zhu, KS Benke… - Epigenetics & …, 2022 - Springer
Background Prenatal vitamin use is recommended before and during pregnancies for
normal fetal development. Prenatal vitamins do not have a standard formulation, but many …

[HTML][HTML] Long noncoding RNA MALAT1 mediates fibrous topography-driven pathologic calcification through trans-differentiation of myoblasts

WJ Kim, J Bae, EH Lee, J Kim, PJ Kim, PX Ma… - Materials Today Bio, 2024 - Elsevier
Prosthesis-induced pathological calcification is a significant challenge in biomaterial
applications and is often associated with various reconstructive medical procedures. It is …