Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer
Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and
bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently …
bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently …
The SLC3 and SLC7 families of amino acid transporters
D Fotiadis, Y Kanai, M Palacín - Molecular aspects of medicine, 2013 - Elsevier
Amino acids are necessary for all living cells and organisms. Specialized transporters
mediate the transfer of amino acids across plasma membranes. Malfunction of these …
mediate the transfer of amino acids across plasma membranes. Malfunction of these …
Thyroid hormone transporters
S Groeneweg, FS van Geest, RP Peeters… - Endocrine …, 2020 - academic.oup.com
Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …
[HTML][HTML] L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia
The L-type amino acid transporter (LAT) family are Na+-independent transporters, which
deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 …
deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 …
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
SH Lecker, RT Jagoe, A Gilbert, M Gomes… - The FASEB …, 2004 - Wiley Online Library
Skeletal muscle atrophy is a debilitating response to starvation and many systemic diseases
including diabetes, cancer, and renal failure. We had proposed that a common set of …
including diabetes, cancer, and renal failure. We had proposed that a common set of …
Amino acid transport across mammalian intestinal and renal epithelia
S Broer - Physiological reviews, 2008 - journals.physiology.org
The transport of amino acids in kidney and intestine is critical for the supply of amino acids to
all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number …
all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number …
[HTML][HTML] Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines
O Yanagida, Y Kanai, A Chairoungdua, DK Kim… - … et Biophysica Acta (BBA …, 2001 - Elsevier
System L is a major nutrient transport system responsible for the transport of large neutral
amino acids including several essential amino acids. We previously identified a transporter …
amino acids including several essential amino acids. We previously identified a transporter …
Molecular and ionic mimicry and the transport of toxic metals
CC Bridges, RK Zalups - Toxicology and applied pharmacology, 2005 - Elsevier
Despite many scientific advances, human exposure to, and intoxication by, toxic metal
species continues to occur. Surprisingly, little is understood about the mechanisms by which …
species continues to occur. Surprisingly, little is understood about the mechanisms by which …
CATs and HATs: the SLC7 family of amino acid transporters
The SLC7 family is divided into two subgroups, the cationic amino acid transporters (the
CAT family, SLC7A1–4) and the glycoprotein-associated amino acid transporters (the gpaAT …
CAT family, SLC7A1–4) and the glycoprotein-associated amino acid transporters (the gpaAT …
Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health
Glutamine together with glucose is essential for body's homeostasis. It is the most abundant
amino acid and is involved in many biosynthetic, regulatory and energy production …
amino acid and is involved in many biosynthetic, regulatory and energy production …