Metastasis is a complex multistep process that involves critical interactions between cancer
cells and a variety of stromal components in the tumor microenvironment, which profoundly …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

The inter-differentiation between cell states promotes cancer cell survival under stress and
fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience …

The cancer stem cell (CSC) model proposes that tumor development and progression are
fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor …

Growth factors in tumor environments are regulators of cell survival and metastasis. Here,
we reveal the dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin …

Tumor relapse in triple negative breast cancer patients has been implicated to
chemoresistant cancer stem cells (CSCs), which under favorable conditions culminate in …

SOX2 is a core pluripotency-associated transcription factor causally related to cancer
initiation, aggressiveness, and drug resistance by driving the self-renewal and seeding …

Background Serous tubal intraepithelial carcinomas (STIC s) have been documented in high‐
grade serous ovarian carcinomas (HGSOC s). However, the rate of association between …

Ovarian high-grade serous carcinomas (HGSCs) are a heterogeneous group of diseases.
They include fallopian-tube-epithelium (FTE)-derived and ovarian-surface-epithelium (OSE) …

Transcription factors are potential targets in disease therapy, particularly in cancer. This is
due to the fact that transcription factors regulate a variety of cellular events, and their …