Intermediate filaments as effectors of cancer development and metastasis: a focus on keratins, vimentin, and nestin

P Sharma, S Alsharif, A Fallatah, BM Chung - Cells, 2019 - mdpi.com
Intermediate filament (IF) proteins make up the largest family of cytoskeletal proteins in
metazoans, and are traditionally known for their roles in fostering structural integrity in cells …

COVID-19. Pandemic surgery guidance

BLDM Brücher, G Nigri, A Tinelli, J Florencio… - 4 OPEN, 2020 - iris.uniroma1.it
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients

W Han, C Hu, ZJ Fan, GL Shen - Scientific Reports, 2021 - nature.com
Keratins (KRTs), the intermediate filament-forming proteins of epithelial cells, are extensively
used as diagnostic biomarkers in cancers and associated with tumorigenesis and …

NF-κB signaling and crosstalk during carcinogenesis

BLDM Brücher, F Lang, IS Jamall - 4open, 2019 - 4open-sciences.org
Transcription factors (TFs) are proteins that control the transcription of genetic information
from DNA to mRNA by binding to specific DNA sequences either on their own or with other …

High KRT8 Expression Independently Predicts Poor Prognosis for Lung Adenocarcinoma Patients

L Xie, Y Dang, J Guo, X Sun, T Xie, L Zhang, Z Yan… - Genes, 2019 - mdpi.com
Keratin 8 (KRT8), a type II basic intermediate filament (IF) protein, is essential for the
development and metastasis of various cancers. In this study, by analyzing RNA-seq data …

Downregulation of cytokeratin 18 induces cellular partial EMT and stemness through increasing EpCAM expression in breast cancer

R Shi, L Liu, F Wang, Y He, Y Niu, C Wang, X Zhang… - Cellular …, 2020 - Elsevier
Induction of epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC)
characteristics underlie the development of metastasis, chemoresistance, and tumor …

Embryonic developmental arrest in the annual killifish Austrolebias charrua: A proteomic approach to diapause III

C Chalar, G Clivio, J Montagne, A Costábile, A Lima… - Plos one, 2021 - journals.plos.org
Diapause is a reversible developmental arrest faced by many organisms in harsh
environments. Annual killifish present this mechanism in three possible stages of …

Circulating extracellular vesicle-derived MARCKSL1 is a potential diagnostic non-invasive biomarker in metastatic colorectal cancer patients

W Rong, S Shao, Y Pu, Q Ji, H Zhu - Scientific Reports, 2023 - nature.com
Extracellular vesicle-derived proteins are closely related to colorectal cancer metastasis,
and early detection and diagnosis of colorectal cancer metastasis is very important to …

Validation study of MARCKSL1 as a prognostic factor in lymph node-negative breast cancer patients

NG Egeland, M Austdal, B van Diermen-Hidle… - Plos one, 2019 - journals.plos.org
Protein expression of Myristoylated alanine-rich C kinase substrate like-1 (MARCKSL1) has
been identified as a prognostic factor in lymph-node negative (LN-) breast cancer patients …

Keratin 8/18 regulate the Akt signaling pathway

Y Lim, S Kim, HN Yoon, NO Ku - International journal of molecular …, 2021 - mdpi.com
Keratin 8 and keratin 18 (K8/K18) are intermediate filament proteins that form the obligate
heteropolymers in hepatocytes and protect the liver against toxins. The mechanisms of …