Since the concept and operational definition of “cognitive frailty”(simultaneous presence of
physical frailty and cognitive impairment without concurrent dementia) were proposed by the …

More than 50 million people have various forms of cognitive impairment basically caused by
neurodegenerative diseases, such as Alzheimer's, Parkinson's, and cerebrovascular …

Highlights•The metabolic responses of zebrafish exposed to PE and PES MPs were
significantly altered.•The enrichment pathway analysis shows disruption of lipid and fatty …

Increased exposure to stress is associated with stress-related disorders, including
depression, anxiety, and neurodegenerative conditions. However, susceptibility to stress is …

Peptides are an important class of molecules with diverse biological activities. Many
endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in …

Cognitive frailty (CF) is the conjunction of cognitive impairment without dementia and
physical frailty. While predictors of each element are well-researched, mechanisms of their …

Advances in sequencing technologies over the past 15 years have led to a substantially
greater appreciation of the importance of the gut microbiome to the health of the host …

The extended endocannabinoid system, also termed endocannabinoidome, participates in
multiple metabolic functions in health and disease. Physical activity can both have an acute …

Background/Objectives: The human gut microbiome is a complex ecosystem of
microorganisms that can influence our health and exercise habits. On the other hand …

Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity has antidepressant-
like effects in preclinical models of stress. In this study, we investigated whether the …