Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …

In Alzheimer's disease, post-mortem studies have shown that the first cortical site where
neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial …

Alzheimer's disease researchers have been intrigued by the selective regional vulnerability
of the brain to amyloid-β plaques and tau neurofibrillary tangles. Post-mortem studies …

The medial temporal lobe (MTL) is connected to the rest of the brain through two main
networks: the anterior-temporal (AT) and the posterior-medial (PM) systems. Given the …

Tauopathies as one of the typical neurodegenerative diseases are characterized by
pathologically aggregated tau in neuron and glia, which causes dysfunction, synapse loss …

Introduction The relative importance of structural magnetic resonance imaging (MRI) and tau
positron emission tomography (PET) to predict diagnosis and cognition in Alzheimer's …

Introduction It is unclear how different proteinopathies (tau, transactive response DNA‐
binding protein 43 [TDP‐43], amyloid β [Aβ], and α‐synuclein) contribute to atrophy within …

Objective Tau pathology is recognized as a primary contributor to neurodegeneration and
clinical symptoms in Alzheimer's disease (AD). This study aims to localize the early tau …

A major focus of Alzheimer's disease (AD) research has been finding sensitive outcome
measures to disease progression in preclinical AD, as intervention studies begin to target …

This study examines the atrophy patterns in the entorhinal and transentorhinal cortices of
subjects that converted from normal cognition to mild cognitive impairment. The regions …