Tumor tissue is composed of cancer cells and surrounding stromal cells with diverse
genetic/epigenetic backgrounds, a situation known as intra-tumoral heterogeneity. Cancer …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …

Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a
long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug …

Cancer cells must adapt their metabolism to meet the energetic and biosynthetic demands
that accompany rapid growth of the primary tumor and colonization of distinct metastatic …

Although survival outcomes of cancer patients have been improved dramatically via
conventional chemotherapy and targeted therapy over the last decades, there are still some …

Metabolic reprogramming is one of the main characteristics of malignant tumors. The
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …

Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …

To sustain their high proliferation rates, most cancer cells rely on glycolytic metabolism, with
production of lactic acid. For many years, lactate was seen as a metabolic waste of glycolytic …

Understanding brain energy metabolism—neuroenergetics—is becoming increasingly
important as it can be identified repeatedly as the source of neurological perturbations …