Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology

S Sato - Journal of physiological anthropology, 2021 - Springer
Malaria is one of the most devastating infectious diseases of humans. It is problematic
clinically and economically as it prevails in poorer countries and regions, strongly hindering …

Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: current state of the art

SR Marcsisin, G Reichard, BS Pybus - Pharmacology & therapeutics, 2016 - Elsevier
Primaquine is the only antimalarial drug available to clinicians for the treatment of relapsing
forms of malaria. Primaquine development and usage dates back to the 1940s and has …

Plasmodium vivax Latent Liver Stage Infection and Relapse: Biological Insights and New Experimental Tools

C Schäfer, G Zanghi, AM Vaughan… - Annual Review of …, 2021 - annualreviews.org
Plasmodium vivax is the most widespread human malaria parasite, in part because it can
form latent liver stages known as hypnozoites after transmission by female anopheline …

Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts

D Rodríguez-Hernández, K Vijayan, R Zigweid… - Nature …, 2023 - nature.com
Drugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the
health and economic burdens caused by malaria worldwide. N-myristoyltransferase (NMT) …

A systematic review of the clinical presentation, treatment and relapse characteristics of human Plasmodium ovale malaria

M Groger, HS Fischer, L Veletzky, A Lalremruata… - Malaria journal, 2017 - Springer
Background Despite increased efforts to control and ultimately eradicate human malaria,
Plasmodium ovale malaria is for the most part outside the focus of research or public health …

Plasmodium ovale wallikeri and P. ovale curtisi infections and diagnostic approaches to imported malaria, France, 2013–2018

V Joste, J Bailly, V Hubert, C Pauc… - Emerging infectious …, 2021 - pmc.ncbi.nlm.nih.gov
We retrospectively analyzed epidemiologic, clinical, and biologic characteristics of 368
Plasmodium ovale wallikeri and 309 P. ovale curtisi infections treated in France during …

A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation

AM Voorberg-van Der Wel, AM Zeeman… - Communications …, 2020 - nature.com
Plasmodium vivax malaria is characterized by repeated episodes of blood stage infection
(relapses) resulting from activation of dormant stages in the liver, so-called hypnozoites …

Artemisinin‐derived antimalarial endoperoxides from bench‐side to bed‐side: chronological advancements and future challenges

MK Tiwari, S Chaudhary - Medicinal Research Reviews, 2020 - Wiley Online Library
Abstract According to WHO World Malaria Report (2018), nearly 219 million new cases of
malaria occurred and a total no. of 435 000 people died in 2017 due to this infectious …

Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a High-transmission Setting

M Groger, L Veletzky, A Lalremruata… - Clinical Infectious …, 2019 - academic.oup.com
Background Plasmodium ovale curtisi and wallikeri are perceived as relapsing malarial
parasites. Contrary to Plasmodium vivax, direct evidence for this hypothesis is scarce. The …

Molecular epidemiology of non-falciparum Plasmodium infections in three different areas of the Ivory Coast

AJS Miezan, AP Gnagne, AV Bedia-Tanoh, EGM Kone… - Malaria Journal, 2023 - Springer
Background Malaria is a major public health problem, particularly in the tropical regions of
America, Africa and Asia. Plasmodium falciparum is not only the most widespread but also …