Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines
Y Ju, JM Carreño, V Simon, K Dawson… - Nature Reviews …, 2023 - nature.com
The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to
stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be …
stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be …
[HTML][HTML] COVID-19, post-acute COVID-19 syndrome (PACS,“long COVID”) and post-COVID-19 vaccination syndrome (PCVS,“post-COVIDvac-syndrome”): Similarities …
F Scholkmann, CA May - Pathology-Research and Practice, 2023 - Elsevier
Worldwide there have been over 760 million confirmed coronavirus disease 2019 (COVID-
19) cases, and over 13 billion COVID-19 vaccine doses have been administered as of April …
19) cases, and over 13 billion COVID-19 vaccine doses have been administered as of April …
Anti-PEG antibodies before and after a first dose of Comirnaty®(mRNA-LNP-based SARS-CoV-2 vaccine)
Y Bavli, BM Chen, G Gross, A Hershko… - Journal of Controlled …, 2023 - Elsevier
The early and massive vaccination campaign in Israel with the mRNA-LNP
Comirnaty®(Pfizer-BioNTech) vaccine against the SARS-CoV-2 virus made available large …
Comirnaty®(Pfizer-BioNTech) vaccine against the SARS-CoV-2 virus made available large …
PEGylated therapeutics in the clinic
The covalent attachment of polyethylene glycol (PEG) to therapeutic agents, termed
PEGylation, is a well‐established and clinically proven drug delivery approach to improve …
PEGylation, is a well‐established and clinically proven drug delivery approach to improve …
[HTML][HTML] Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions
SM Moghimi, HB Haroon, A Yaghmur… - Journal of Controlled …, 2023 - Elsevier
The complement system, professional phagocytes and other cells such as Natural killer cells
and mast cells are among the important components of the innate arm of the immune …
and mast cells are among the important components of the innate arm of the immune …
Strategies to reduce the risks of mRNA drug and vaccine toxicity
D Bitounis, E Jacquinet, MA Rogers… - Nature Reviews Drug …, 2024 - nature.com
Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …
enabled the rapid development and administration of billions of coronavirus disease 2019 …
Exploring the role of polymers to overcome ongoing challenges in the field of extracellular vesicles
Extracellular vesicles (EVs) are naturally occurring nanoparticles released from all
eucaryotic and procaryotic cells. While their role was formerly largely underestimated, EVs …
eucaryotic and procaryotic cells. While their role was formerly largely underestimated, EVs …
Investigating generation of antibodies against the lipid nanoparticle vector Following COVID-19 vaccination with an mRNA vaccine
R Münter, E Sørensen, RB Hasselbalch… - Molecular …, 2023 - ACS Publications
Despite the success of mRNA-based vaccines against infectious diseases (including COVID-
19), safety concerns have been raised relating to the lipid nanoparticles (LNPs) used to …
19), safety concerns have been raised relating to the lipid nanoparticles (LNPs) used to …
Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route
H Takata, T Shimizu, R Yamade, NE Elsadek… - Journal of Controlled …, 2023 - Elsevier
Modifying the surface of nanoparticles with polyethylene glycol (PEG) is a commonly used
approach for improving the in vitro stability of nanoparticles such as liposomes and …
approach for improving the in vitro stability of nanoparticles such as liposomes and …
Dose-Dependent Production of Anti-PEG IgM after Intramuscular PEGylated-Hydrogenated Soy Phosphatidylcholine Liposomes, but Not Lipid Nanoparticle …
CN Subasic, NJ Butcher, RF Minchin… - Molecular …, 2023 - ACS Publications
PEGylated lipid nanoparticle-based Covid-19 vaccines, including Pfizer's BNT162b2 and
Moderna's mRNA-1273, have been shown to stimulate variable anti-PEG antibody …
Moderna's mRNA-1273, have been shown to stimulate variable anti-PEG antibody …