Low back pain (LBP) is one of the major disabling health conditions among older adults
aged 60 years or older. While most causes of LBP among older adults are non-specific and …

Osteosarcoma is the most common primary malignancy of bone in children and young
adults. This tumor has a very heterogeneous genetic profile and lacks any consistent …

Simple Summary Osteosarcoma (OS) is the most common bone cancer in children. OS most
commonly arises in the legs, but can arise in any bone, including the spine, head or neck …

Purpose Various techniques for anterior column reconstruction have been described after
en bloc resection of spinal tumors. Limited evidence exists regarding one being superior to …

Purpose There are conflicting findings about the effect of resection margins on local
recurrence in osteosarcoma after surgery. In this meta-analysis, we examined the …

BACKGROUND CONTEXT Malignant primary spinal tumors are rare making it difficult to
perform large studies comparing epidemiologic, survival, and treatment trends. We …

Primary and metastatic tumors of the spine represent a significant cause of patient morbidity,
and present a management challenge to treating providers. From a neurosurgical …

Circular RNAs are novel identified type of endogenous non-coding RNAs, which exert vital
functions in human and animals. However, the in-depth role of circular RNAs in the …

Osteosarcoma, including spinal osteosarcoma, has properties of high degree of malignancy,
high rate of recurrence, and high incidence of metastasis. microRNAs can exert oncogenic …

Spine tumors are among the most difficult tumors to treat given their proximity to the spinal
cord. Despite advances in adjuvant therapies, surgery remains a critical component of …