Despite improvement of antifungal therapies over the last 30 years, the phenomenon of
antifungal resistance is still of major concern in clinical practice. In the last 10 years the …

Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …

Invasive fungal infections are a major cause of morbidity and mortality in immunodeficient
individuals (such as AIDS patients) and in transplant recipients or tumor patients undergoing …

Aspergillus fumigatus is the most important airborne fungal pathogen, causing severe
infections with invasive growth in immunocompromised patients. The fungal cell wall (CW) …

Macrolides are a diverse class of hydrophobic compounds characterized by a macrocyclic
lactone ring and distinguished by variable side chains/groups. Some of the most well …

Fungal infections represent a serious problem for patients with immune systems
compromized either by HIV infection, or administration of immunosuppressive drugs during …

The systematic modification of natural products through diverted total synthesis is a powerful
concept for the systematic modification of natural products with the aim of studying …

Amphotericin B (AmB) is a well known antifungal and antiprotozoal antibiotic used in the
clinic for several decades. Clinical applications of AmB, however, are limited by its …

Amphotericin B is the archetype for small molecules that form transmembrane ion channels.
However, despite extensive study for more than five decades, even the most basic features …

Pimaricin (natamycin) is a small polyene macrolide antibiotic used worldwide. This efficient
antimycotic and antiprotozoal agent, produced by several soil bacterial species of the genus …