Leishmania is a genus of protozoan parasites that are transmitted by the bite of
phlebotomine sandflies and give rise to a range of diseases (collectively known as …

Two major obstacles facing cancer nanomedicine are the tendency of nanoparticles to be
taken up by normal tissues and organs and the nanoparticles' inability to efficiently penetrate …

Atherosclerosis (AS), a leading cause of death worldwide, involves chronic macrophage
inflammation from its initiation to the emergence of complications. Targeting plaque …

Aberrant glucose metabolism and immune evasion are recognized as two hallmarks of
cancer, which contribute to poor treatment efficiency and tumor progression. Herein, a novel …

Glioblastoma (GBM) is a complex ecosystem that includes a heterogeneous tumor
population and the tumor-immune microenvironment (TIME), prominently containing tumor …

Humanized mouse models that have received human cells or tissue transplants are
extremely useful in basic and applied human disease research. Highly immunodeficient …

To directly study complex human hemato-lymphoid system physiology and respective
system-associated diseases in vivo, human-to-mouse xenotransplantation models for …

Checkpoint inhibition immunotherapy has revolutionized cancer treatment, but many
patients show resistance. Here we perform integrative transcriptomic and proteomic …

Since an immunoreceptor tyrosine‐based inhibition motif (ITIM) was first identified in the
intracytoplasmic domain of FcγRIIB, ITIMs have been found in a large number of inhibitory …

Transplantation of human hematopoietic stem cells into severely immunocompromised
newborn mice allows the development of a human hematopoietic and immune system in …