Antifungal resistance and the role of new therapeutic agents

A Logan, A Wolfe, JC Williamson - Current Infectious Disease Reports, 2022 - Springer
Abstract Purpose of Review Advances in health care over time have led to an evolution in
the epidemiology of invasive fungal infections. There is an increasing concern for antifungal …

Clinical safety and efficacy of novel antifungal, fosmanogepix, for the treatment of candidaemia: results from a Phase 2 trial

PG Pappas, JA Vazquez, I Oren… - Journal of …, 2023 - academic.oup.com
Background Fosmanogepix is a first-in-class antifungal targeting the fungal enzyme Gwt1,
with broad-spectrum activity against yeasts and moulds, including multidrug-resistant fungi …

[HTML][HTML] Candida auris‒associated hospitalizations, United States, 2017–2022

K Benedict, K Forsberg, JAW Gold… - Emerging infectious …, 2023 - ncbi.nlm.nih.gov
Using a large US hospital database, we describe 192 Candida auris‒associated
hospitalizations during 2017–2022, including 38 (20%) C. auris bloodstream infections …

Molecular Techniques and Target Selection for the Identification of Candida spp. in Oral Samples

J Magalhães, MJ Correia, RM Silva, AC Esteves… - Applied Sciences, 2022 - mdpi.com
Candida species are the causative agent of oral candidiasis, with medical devices being
platforms for yeast anchoring and tissue colonization. Identifying the infectious agent …

A Membrane‐Targeted Photosensitizer Prevents Drug Resistance and Induces Immune Response in Treating Candidiasis

MY Wu, X Xu, R Hu, Q Chen, L Chen, Y Yuan… - Advanced …, 2023 - Wiley Online Library
Abstract Candida albicans (C. albicans), a ubiquitous polymorphic fungus in humans,
causes different types of candidiasis, including oral candidiasis (OC) and vulvovaginal …

A Cecropin-4 Derived Peptide C18 Inhibits Candida albicans by Disturbing Mitochondrial Function

CQ Sun, J Peng, LB Yang, ZL Jiao, LX Zhou… - Frontiers in …, 2022 - frontiersin.org
Global burden of fungal infections and related health risk has accelerated at an incredible
pace, and multidrug resistance emergency aggravates the need for the development of new …

The Guardian of Vision: Intelligent Bacteriophage‐Based Eyedrops for Clinical Multidrug‐Resistant Ocular Surface Infections

L Chen, MY Wu, SL Chen, R Hu, Y Wang… - Advanced …, 2024 - Wiley Online Library
Clinical multidrug‐resistant Pseudomonas aeruginosa (MDR‐PA) is the leading cause of
refractory bacterial keratitis (BK). However, the reported BK treatment methods lack …

Candidemia in Adult Patients in the ICU: A Reappraisal of Susceptibility Testing and Antifungal Therapy

DB Chastain, BP White, PJ Tu, S Chan… - Annals of …, 2024 - journals.sagepub.com
Objective: To provide updates on the epidemiology and recommendations for management
of candidemia in patients with critical illness. Data Sources: A literature search using the …

Clinical manifestations and treatment of candidemia caused by different Candida species: a retrospective study

C Zhang, S Wu, X Chen, H Yang, W Feng, T Yuan… - BMC Infectious …, 2024 - Springer
Objective Candidemia leads to higher mortality and longer hospital-stay. While the studies
about the clinical manifestations of candidemia caused by different Candida species and the …

A Scoping Review of the Changing Epidemiology and Risk Factors of Endogenous Candida Ocular Infections

Z Pek, JT Bork - Current Fungal Infection Reports, 2023 - Springer
Abstract Purpose of Review There is controversy surrounding the true incidence of ocular
infection in patients with candidemia and the best approach to screening for this condition …