Phages differ substantially in the bacterial hosts that they infect. Their host range is
determined by the specific structures that they use to target bacterial cells. Tailed phages …

Gram-negative bacteria characteristically are surrounded by an additional membrane layer,
the outer membrane. Although outer membrane components often play important roles in …

With a significant role in material sciences, physics,(soft matter) chemistry, and biology, the
transmission electron microscope is one of the most widely applied structural analysis tool to …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

The first stages of productive bacteriophage infections of bacterial host cells require efficient
adsorption to the cell surface followed by ejection of phage DNA into the host cytoplasm. To …

▪ Abstract Electron tomography (ET) is uniquely suited to obtain three-dimensional
reconstructions of pleomorphic structures, such as cells, organelles or supramolecular …

Bacteriophage-encoded endolysins degrading the bacterial peptidoglycan are promising
antibacterials for combating antibiotic-resistant bacteria. However, endolysins have limited …

The conjunction of insights from structural biology, solution biochemistry, genetics, and
single-molecule biophysics has provided a renewed impetus for the construction of …

In 1952, Hershey and Chase used bacteriophage T2 genome delivery inside Escherichia
coli to demonstrate that DNA, not protein, is the genetic material. Over 70 years later, our …

Membrane proteins are central to many biological processes, and the interactions between
transmembrane protein receptors and their ligands are of fundamental importance in …