Congenital hypothyroidism (CH) occurs in approximately 1: 2,000 to 1: 4,000 newborns. The
clinical manifestations are often subtle or not present at birth. This likely is due to trans …

There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

More than 2% of the adult US population harbors a pancreatic cyst. These often pose a
difficult management problem because conventional criteria cannot always distinguish cysts …

Adrenal tumors autonomously producing cortisol cause Cushing's syndrome,,,. We
performed exome sequencing of 25 tumor-normal pairs and identified 2 subgroups. Eight …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors and
mediate the effects of numerous hormones and neurotransmitters. The nearly 1000 GPCRs …

G protein-coupled receptors (GPCRs) regulate many cellular and physiological processes,
responding to a diverse range of extracellular stimuli including hormones, neurotransmitters …

Pancreatic cancer arises from noninvasive precursor lesions, including pancreatic
intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and …

Pseudohypoparathyroidism exemplifies an unusual form of hormone resistance as the
underlying molecular defect is a partial deficiency of the α subunit of the stimulatory G …

A relation between the chemical structure of a xenobiotic and its steroidal action has not yet
been clearly established. Thus, it is not possible to define the estrogenic potency of different …