A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Background In sea urchins, spermatozoan motility is altered by chemotactic peptides, giving
rise to the assumption that mammalian eggs also emit chemotactic agents that guide …

Ion channels are important therapeutic targets due to their plethoric involvement in
physiological and pathological consequences. The transient receptor potential cation …

The sperm‐specific CatSper channel controls the intracellular Ca2+ concentration ([Ca2+] i)
and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by …

Transient Receptor Potential Melastatin–8 (TRPM8), a recently identified member of the
transient receptor potential (TRP) family of ion channels, is activated by mild cooling and by …

BACKGROUND Intensive research on sperm ion channels has identified members of
several ion channel families in both mouse and human sperm. Gene knock-out studies have …

Calcium is an essential ion which regulates sperm motility, capacitation and the acrosome
reaction (AR), three processes necessary for successful fertilization. The AR enables the …

The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …

The molecular mechanisms underlying Ca2+ entry into sperm are now much more well
defined thanks to direct recordings of mature sperm cells. This article reviews the function of …

Mammals possess two types of adipose tissue, white (WAT) and brown (BAT). The
uncoupling protein 1 (UCP1) is a hallmark of BAT, being the pivotal player for cold-induced …