Bacterial origins of human cell-autonomous innate immune mechanisms
The cell-autonomous innate immune system enables animal cells to resist viral infection.
This system comprises an array of sensors that, after detecting viral molecules, activate the …
This system comprises an array of sensors that, after detecting viral molecules, activate the …
Mechanisms and clinical importance of bacteriophage resistance
JE Egido, AR Costa… - FEMS microbiology …, 2022 - academic.oup.com
We are in the midst of a golden age of uncovering defense systems against bacteriophages.
Apart from the fundamental interest in these defense systems, and revolutionary applications …
Apart from the fundamental interest in these defense systems, and revolutionary applications …
Heightened innate immune responses in the respiratory tract of COVID-19 patients
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection have posed a severe threat to global public health. It is unclear how the human …
infection have posed a severe threat to global public health. It is unclear how the human …
Prokaryotic viperins produce diverse antiviral molecules
Viperin is an interferon-induced cellular protein that is conserved in animals. It has
previously been shown to inhibit the replication of multiple viruses by producing the …
previously been shown to inhibit the replication of multiple viruses by producing the …
Lipid droplet functions beyond energy storage
Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important
for energy metabolism. Their function in energy storage is firmly established and …
for energy metabolism. Their function in energy storage is firmly established and …
Expanding roles for lipid droplets
MA Welte - Current biology, 2015 - cell.com
Lipid droplets are the intracellular sites for neutral lipid storage. They are critical for lipid
metabolism and energy homeostasis, and their dysfunction has been linked to many …
metabolism and energy homeostasis, and their dysfunction has been linked to many …
A naturally occurring antiviral ribonucleotide encoded by the human genome
Viral infections continue to represent major challenges to public health, and an enhanced
mechanistic understanding of the processes that contribute to viral life cycles is necessary …
mechanistic understanding of the processes that contribute to viral life cycles is necessary …
[HTML][HTML] Interferon-stimulated genes as enhancers of antiviral innate immune signaling
The ability of a host to curb a viral infection is heavily reliant on the effectiveness of an initial
antiviral innate immune response, resulting in the upregulation of interferon (IFN) and …
antiviral innate immune response, resulting in the upregulation of interferon (IFN) and …
Lipid droplets, lipophagy, and beyond
CW Wang - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2016 - Elsevier
Lipids are essential components for life. Their various structural and physical properties
influence diverse cellular processes and, thereby, human health. Lipids are not genetically …
influence diverse cellular processes and, thereby, human health. Lipids are not genetically …
Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response
Lipid droplets (LDs) are increasingly recognized as critical organelles in signalling events,
transient protein sequestration and inter-organelle interactions. However, the role LDs play …
transient protein sequestration and inter-organelle interactions. However, the role LDs play …