Animal models for influenza research: strengths and weaknesses

TQ Nguyen, R Rollon, YK Choi - Viruses, 2021 - mdpi.com
Influenza remains one of the most significant public health threats due to its ability to cause
high morbidity and mortality worldwide. Although understanding of influenza viruses has …

T cell immunity against influenza: The long way from animal models towards a real-life universal flu vaccine

A Schmidt, D Lapuente - Viruses, 2021 - mdpi.com
Current flu vaccines rely on the induction of strain-specific neutralizing antibodies, which
leaves the population vulnerable to drifted seasonal or newly emerged pandemic strains …

Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in inbred babraham pigs and outbred pigs

M Edmans, A McNee, E Porter, E Vatzia… - Frontiers in …, 2021 - frontiersin.org
We have used the pig, a large natural host animal for influenza with many physiological
similarities to humans, to characterize αβ, γδ T cell and antibody (Ab) immune responses to …

Improving immunological insights into the ferret model of human viral infectious disease

J Wong, D Layton, AK Wheatley… - Influenza and Other …, 2019 - Wiley Online Library
Ferrets are a well‐established model for studying both the pathogenesis and transmission of
human respiratory viruses and evaluation of antiviral vaccines. Advanced immunological …

[HTML][HTML] Establishment of a pig influenza challenge model for evaluation of monoclonal antibody delivery platforms

A McNee, TRF Smith, B Holzer, B Clark… - The Journal of …, 2020 - journals.aai.org
Abstract mAbs are a possible adjunct to vaccination and drugs in treatment of influenza virus
infection. However, questions remain whether small animal models accurately predict …

Development of Virus-like Particle Plant-Based Vaccines against Avian H5 and H9 Influenza A Viruses

OA Elbohy, M Iqbal, JM Daly, SP Dunham - Veterinary Sciences, 2024 - mdpi.com
Simple Summary Avian influenza virus (AIV) is a highly infectious viral disease, some
subtypes of which (eg, H5 and H9) cause high mortality in poultry and can be transmitted to …

Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults

Y Cao, Z Guo, P Vangala, E Donnard, P Liu… - BioRxiv, 2020 - biorxiv.org
Influenza virus infections are major causes of morbidity and mortality. Research using
cultured cells, bulk tissue, and animal models cannot fully capture human disease dynamics …

Quantitative measurement of influenza virus transmission in animal model: an overview of current state

G Onkhonova, A Gudymo, M Kosenko, V Marchenko… - Biophysical …, 2023 - Springer
Influenza virus transmission is a crucial factor in understanding the spread of the virus within
populations and developing effective control strategies. Studying the transmission patterns …

[PDF][PDF] Cell Immunity against Influenza: The Long Way from Animal Models Towards a Real-Life Universal Flu Vaccine. Viruses 2021, 13, 199

A Schmidt, DT Lapuente - 2021 - pdfs.semanticscholar.org
Current flu vaccines rely on the induction of strain-specific neutralizing antibodies, which
leaves the population vulnerable to drifted seasonal or newly emerged pandemic strains …

Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs

M Edmans, A McNee, E Porter, E Vatzia, B Paudyal… - bioRxiv, 2020 - biorxiv.org
We have used the pig, a large natural host animal for influenza with many physiological
similarities to humans, to characterize αβ, γδ T cell and antibody (Ab) immune responses to …