Aging-induced alternations of vasculature structures, phenotypes, and functions are key in
the occurrence and development of vascular aging-related diseases. Multiple molecular and …

(1) Background: high-density lipoproteins (HDLs) exhibit antioxidant and anti-inflammatory
properties that play an important role in preventing the development of atherosclerotic …

Background Exercise can protect myocardial infarction (MI) and downregulate cardiac
Homeodomain-Interacting Protein Kinase 2 (HIPK2). However, the role of HIPK2 in MI is …

Reperfusion therapy is widely used to treat acute myocardial infarction. However, its efficacy
is limited by myocardial ischemia-reperfusion injury (MIRI), which occurs paradoxically due …

Apolipoprotein AI (ApoA-I) is a member of blood apolipoproteins, it is the main component of
High density lipoprotein (HDL). ApoA-I undergoes a series of complex processes from its …

Abstract Background The AEGIS-II trial hypothesized that CSL112, an intravenous
formulation of human apoA-I, would lower the risk of plaque disruption, decreasing the risk …

Approximately 12% of patients with acute myocardial infarction (AMI) experience a recurrent
major adverse cardiovascular event within 1 year of their primary event, with most occurring …

Myocardial infarction, usually caused by the rupture of atherosclerotic plaque, leads to
irreversible ischemic cardiomyocyte death within hours followed by impaired cardiac …

High-density lipoproteins (HDL) are complex endogenous nanoparticles involved in
important functions such as reverse cholesterol transport and immunomodulatory activities …

Cardiovascular diseases are the leading cause of death worldwide. Although there have
been substantial advances over the last decades, recurrent adverse cardiovascular events …