PDZ domains are abundant protein interaction modules that often recognize short amino
acid motifs at the C-termini of target proteins. They regulate multiple biological processes …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

We present a large-scale approach to investigate the functional consequences of sequence
variation in a protein. The approach entails the display of hundreds of thousands of protein …

The concept of engineering robust protein scaffolds for novel binding functions emerged 20
years ago, one decade after the advent of recombinant antibody technology. Early examples …

More than 300 different types of protein post‐translational modifications (PTMs) have been
described, many of which are known to have pivotal roles in cellular physiology and …

Systematic and quantitative analysis of protein phosphorylation is revealing dynamic
regulatory networks underlying cellular responses to environmental cues. However …

Membrane protein efflux pumps confer antibiotic resistance by extruding structurally distinct
compounds and lowering their intracellular concentration. Yet, there are no clinically …

There is an ever-increasing demand to select specific, high-affinity binding molecules
against targets of biomedical interest. The success of such selections depends strongly on …

Synthetic binding proteins are constructed using nonantibody molecular scaffolds. Over the
last two decades, in‐depth structural and functional analyses of synthetic binding proteins …

Herein we review contemporary synthetic and protein design strategies to stabilize the α-
helical motif in short peptides and miniature proteins. Advances in organometallic catalyst …