Persistent human papillomavirus (HPV) infection is recognized as the main cause of cervical
cancer and other malignant cancers. Although early detection and treatment can be …

Immune tolerance is necessary to prevent the immune system from reacting against self, and
thus to avoid the development of autoimmune diseases. In this review, we discuss key …

CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-
mediated tumor rejection, but the underlying mechanisms are incompletely understood …

Death receptors (DRs) are members of the tumor necrosis factor receptor superfamily that
possess a cytoplasmic death domain (DD). DRs regulate important operational and …

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …

Skin-derived dendritic cells (DCs) play a crucial role in the maintenance of immune
homeostasis due to their role in antigen trafficking from the skin to the draining lymph nodes …

Dendritic cells (DCs) are professional antigen presenting cells displaying the unique
capability to activate naïve T cells. DCs react to pathogen encounter also by the production …

Splenic dendritic cells (DCs) present blood-borne antigens to lymphocytes to promote T cell
and antibody responses. The cues involved in positioning DCs in areas of antigen exposure …

Dendritic cells (DCs) are specialized sentinels responsible for coordinating adaptive
immunity. This function is dependent upon coupled sensitivity to environmental signs of …

Background—Immunoinflammatory mechanisms are implicated in the atherogenic process.
The polarization of the immune response and the nature of the immune cells involved …