Moyamoya disease (MMD) is a rare cerebrovascular disorder with unknown etiology. MMD
is characterized by progressive narrowing of arteries of the brain and the formation of a …

The covalent attachment of ubiquitin is a common regulatory mechanism in various proteins.
Although it has long been thought that the substrates of ubiquitination are limited to proteins …

Taking the significance of the special microenvironment for tumor cell survival into account,
disrupting tumor redox homeostasis is highly prospective for improving therapeutic efficacy …

Ubiquitylation is a widespread post-translational protein modification in eukaryotes and
marks bacteria that invade the cytosol as cargo for antibacterial autophagy,–. The identity of …

Excessive levels of saturated fatty acids are toxic to cells, although the basis for this
lipotoxicity remains incompletely understood. Here, we analyzed the transcriptome …

In breast cancer, genetic heterogeneity, the lack of actionable targets and immune evasion
all contribute to the limited clinical response rates to immune checkpoint blockade therapy …

ISG15 is an interferon-stimulated, ubiquitin-like protein that can conjugate to substrate
proteins (ISGylation) to counteract microbial infection, but the underlying mechanisms …

RNF213 is the major susceptibility factor for Moyamoya disease, a progressive
cerebrovascular disorder that often leads to brain stroke in adults and children …

Psoriasis is a severe disease associated with the disturbance of metabolism and
inflammation, but the molecular mechanisms underlying these aspects of psoriasis …

The phosphorylation status of oncoproteins is regulated by both kinases and phosphatases.
Kinase inhibitors are rarely sufficient for successful cancer treatment, and phosphatases …