Here we present a guide to ion mobility mass spectrometry experiments, which covers both
linear and nonlinear methods: what is measured, how the measurements are done, and how …

Although nonnative protein conformations, including intermediates along the folding
pathway and kinetically trapped misfolded species that disfavor the native state, are rarely …

In bottom-up proteomics, peptides are separated by liquid chromatography with elution peak
widths in the range of seconds, whereas mass spectra are acquired in about 100 …

In liquid chromatography-mass spectrometry (LC-MS)-based proteomics, many precursors
elute from the column simultaneously. In data-dependent analyses, these precursors are …

Here we describe a detailed protocol for both data collection and interpretation with respect
to ion mobility–mass spectrometry analysis of large protein assemblies. Ion mobility is a …

Proteomics is the large-scale study of the structure and function of proteins in complex
biological sample. Such an approach has the potential value to understand the complex …

One difficulty in using ion mobility (IM) mass spectrometry (MS) to improve the specificity of
peptide ion assignments is that IM separations are performed using a range of pressures …

The size and shape of peptide ions in the gas phase are an under-explored dimension for
mass spectrometry-based proteomics. To investigate the nature and utility of the peptide …

Antibiotic resistance has emerged as an imminent pandemic. Rapid diagnostic assays
distinguish bacterial infections from other diseases and aid antimicrobial stewardship …

Ion Mobility Spectrometry (IMS) is a widely used and 'well-known'technique of ion separation
in the gaseous phase based on the differences of ion mobilities under an electric field. This …