Mechanisms of vascular aging
Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …
Hypertension-induced cognitive impairment: from pathophysiology to public health
Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …
Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial …
Aging-induced structural and functional alterations of the neurovascular unit lead to
impairment of neurovascular coupling responses, dysregulation of cerebral blood flow, and …
impairment of neurovascular coupling responses, dysregulation of cerebral blood flow, and …
Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain
Age-related phenotypic changes of cerebromicrovascular endothelial cells lead to
dysregulation of cerebral blood flow and blood-brain barrier disruption, promoting the …
dysregulation of cerebral blood flow and blood-brain barrier disruption, promoting the …
Retinal biomarkers for Alzheimer's disease and vascular cognitive impairment and dementia (VCID): implication for early diagnosis and prognosis
Cognitive impairment and dementia are major medical, social, and economic public health
issues worldwide with significant implications for life quality in older adults. The leading …
issues worldwide with significant implications for life quality in older adults. The leading …
Obesity-induced cognitive impairment in older adults: a microvascular perspective
P Balasubramanian, T Kiss… - American Journal …, 2021 - journals.physiology.org
Over two-thirds of individuals aged 65 and older are obese or overweight in the United
States. Epidemiological data show an association between the degree of adiposity and …
States. Epidemiological data show an association between the degree of adiposity and …
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults
L Toth, A Czigler, E Hegedus, H Komaromy, K Amrein… - Geroscience, 2022 - Springer
Impairment of moment-to-moment adjustment of cerebral blood flow (CBF) to the increased
oxygen and energy requirements of active brain regions via neurovascular coupling (NVC) …
oxygen and energy requirements of active brain regions via neurovascular coupling (NVC) …
Nutrition strategies promoting healthy aging: From improvement of cardiovascular and brain health to prevention of age-associated diseases
M Fekete, Z Szarvas, V Fazekas-Pongor, A Feher… - Nutrients, 2022 - mdpi.com
Background: An increasing number of studies suggest that diet plays an important role in
regulating aging processes and modulates the development of the most important age …
regulating aging processes and modulates the development of the most important age …
Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
T Pandics, D Major, V Fazekas-Pongor, Z Szarvas… - Geroscience, 2023 - Springer
The aging population worldwide is facing a significant increase in age-related non-
communicable diseases, including cardiovascular and brain pathologies. This …
communicable diseases, including cardiovascular and brain pathologies. This …
Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related …
Aging is associated with increased oxidative stress in vascular endothelial and smooth
muscle cells, which contribute to the development of a wide range of diseases affecting the …
muscle cells, which contribute to the development of a wide range of diseases affecting the …