Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature

S Wolking, E Schaeffeler, H Lerche, M Schwab… - Clinical …, 2015 - Springer
ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

Pharmacogenetics of drug-resistant epilepsy (review of literature)

B Smolarz, M Makowska, H Romanowicz - International journal of …, 2021 - mdpi.com
Pharmacogenomic studies in epilepsy are justified by the high prevalence rate of this
disease and the high cost of its treatment, frequent drug resistance, different response to the …

Towards realizing the vision of precision medicine: AI based prediction of clinical drug response

J de Jong, I Cutcutache, M Page, S Elmoufti, C Dilley… - Brain, 2021 - academic.oup.com
Accurate and individualized prediction of response to therapies is central to precision
medicine. However, because of the generally complex and multifaceted nature of clinical …

Genetic variations associated with pharmacoresistant epilepsy

N Cárdenas-Rodríguez… - Molecular …, 2020 - spandidos-publications.com
Epilepsy is a common, serious neurological disorder worldwide. Although this disease can
be successfully treated in most cases, not all patients respond favorably to medical …

[HTML][HTML] Prevalence of epilepsy in Iran: a meta-analysis and systematic review

K Sayehmiri, H Tavan, F Sayehmiri… - Iranian journal of …, 2014 - ncbi.nlm.nih.gov
Prevalence of Epilepsy in Iran: A Meta-Analysis and Systematic Review - PMC Back to Top
Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main …

[HTML][HTML] ABCG2, SCN1A and CYP3A5 genes polymorphism and drug-resistant epilepsy in children: A case-control study

SF Mousavi, K Hasanpour, M Nazarzadeh, A Adli… - Seizure, 2022 - Elsevier
Abstract Purpose Drug Resistant-Epilepsy is still a major challenge in pharmacotherapy of
epilepsy. Pharmacogenetic pathways are one of the most important elements that can help …

Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study

E Foroozani, R Ghiasvand, M Mohammadianpanah… - Scientific Reports, 2020 - nature.com
One of the reasons for high mortality of breast cancer (BC) is long delay in seeking medical
care and end stage at presentation. This study was designed to measure the association …

[HTML][HTML] On the two largest Q-eigenvalues of graphs

JF Wang, F Belardo, QX Huang, B Borovićanin - Discrete Mathematics, 2010 - Elsevier
In this paper, we first give an upper bound for the largest signless Laplacian eigenvalue of a
graph and find all the extremal graphs. Secondly, we consider the second-largest signless …

[HTML][HTML] The potential implication of SCN1A and CYP3A5 genetic variants on antiepileptic drug resistance among Egyptian epileptic children

WMMA El Fotoh, MSE Habib, AA ALrefai, ZA Kasemy - Seizure, 2016 - Elsevier
Purpose Despite the advances in the pharmacological treatment of epilepsy,
pharmacoresistance still remains challenging. Understanding of the pharmacogenetic …

Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders

J Sagahón‐Azúa, SE Medellín‐Garibay… - Pharmacology …, 2021 - Wiley Online Library
Over the last few years, fluoxetine has been one of the most prescribed medications for the
treatment of diverse psychiatric conditions in Mexico. Fluoxetine therapeutic effect is …