A few months ago the International Human Genome Sequencing Consortium (IHGSC)
published a 61-page paper on the human genome (IHGSC, Nature 409 (2001) 860). Here …

By conventional wisdom, a feature that occurs too often or too rarely in a genome can
indicate a functional element. To infer functionality from frequency, it is crucial to precisely …

Here we present a study of statistical correlations among different positions in DNA
sequences and their implications by directly using the autocorrelation function. Such an …

Spatial fluctuations of guanine and cytosine base content (GC%) are studied by spectral
analysis for the complete set of human genomic DNA sequences. We find that (i) 1∕ f α …

Macromolecular sedimentation in inhomogeneous media is of great practical importance.
Dynamic density gradients have a long tradition in analytical ultracentrifugation, and are …

A new approach to estimate the Shannon entropy of a long-range correlated sequence is
proposed. The entropy is written as the sum of two terms corresponding respectively to …

The sequencing of prokaryotic genomes covering a wide taxonomic range has sparked
renewed interest in intrachromosomal compositional (GC) heterogeneity, largely in view of …

Three statistical/mathematical analyses are carried out on isochore sequences: spectral
analysis, analysis of variance, and segmentation analysis. Spectral analysis shows that …

Promoters are DNA regulatory elements located near the transcription start site and are
responsible for regulating the transcription of genes. DNA fragments arranged in a certain …

Essential genes are required for the reproduction and survival of an organism. Rapid
identification of essential genes has practical application value in biomedicine. Information …