The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized
transmembrane and secretory proteins—essential for cellular structure–function and for both …

The unfolded protein response (UPR) plays a central role in regulating endoplasmic
reticulum (ER) and global cellular physiology in response to pathologic ER stress. The UPR …

The endoplasmic reticulum (ER) is the major site of membrane biogenesis in most
eukaryotic cells. As the entry point to the secretory pathway, it handles more than 10,000 …

The endoplasmic reticulum (ER) is the key organelle for membrane biogenesis. Most lipids
are synthesized in the ER, and most membrane proteins are first inserted into the ER …

Mammalian TFEB and TFE3, as well as their ortholog in Caenorhabditis elegans HLH‐30,
play an important role in mediating cellular response to a variety of stress conditions …

Light chain (LC) amyloidosis (AL) involves the toxic aggregation of amyloidogenic
immunoglobulin LCs secreted from a clonal expansion of diseased plasma cells. Current AL …

Dysfunction of the endoplasmic reticulum (ER), so-called ER stress, is accompanied with
accumulation of unfolded proteins in the ER. Eukaryotic cells commonly have an ER-located …

Pancreatic cancer (PC) is one of the most aggressive malignancies, characterized by an
increasing incidence and unfavorable prognosis. Despite recent advances, surgical …

Pharmacological activation of the activating transcription factor 6 (ATF6) arm of the unfolded
protein response (UPR) has proven useful for ameliorating proteostasis deficiencies in …