Inflammasome-mediated inflammation in liver ischemia-reperfusion injury

MB Jiménez-Castro, ME Cornide-Petronio… - Cells, 2019 - mdpi.com
Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical
procedures including hepatic resection and liver transplantation, and represents the main …

Modern work-up and extended resection in perihilar cholangiocarcinoma: the AMC experience

F Rassam, E Roos, KP Van Lienden… - … archives of surgery, 2018 - Springer
Aim Perihilar cholangiocarcinoma (PHC) is a challenging disease and requires aggressive
surgical treatment in order to achieve curation. The assessment and work-up of patients with …

Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia–reperfusion injury

M Ge, W Yao, D Yuan, S Zhou, X Chen, Y Zhang… - Cell Death & …, 2017 - nature.com
Cytoprotective gene heme oxygenase 1 (HO-1) could be induced by nuclear factor E2-
related factor 2 (Nrf2) nuclear translocation. The purpose of this study was to determine the …

Hemorheological and microcirculatory factors in liver ischemia-reperfusion injury—An update on pathophysiology, molecular mechanisms and protective strategies

N Nemeth, K Peto, Z Magyar, Z Klarik, G Varga… - International journal of …, 2021 - mdpi.com
Hepatic ischemia-reperfusion injury (IRI) is a multifactorial phenomenon which has been
associated with adverse clinical outcomes. IRI related tissue damage is characterized by …

Associations of oxidative stress and postoperative outcome in liver surgery with an outlook to future potential therapeutic options

T Senoner, S Schindler, S Stättner… - Oxidative Medicine …, 2019 - Wiley Online Library
Several types of surgical procedures have shown to elicit an inflammatory stress response,
leading to substantial cytokine production and formation of oxygen‐based or nitrogen …

Liver ischemia and reperfusion injury. Pathophysiology and new horizons in preconditioning and therapy

PCG Nakazato, JP Victorino, CF Fina… - Acta cirurgica …, 2018 - SciELO Brasil
It is well known that during hepatic operative procedures, it is often critical that the irrigation
is interrupted to avoid possible bleeding, blood transfusions, variable intensities, and their …

Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3

X Li, Z Wang, C Jiao, Y Zhang, N Xia, W Yu… - Journal of Translational …, 2023 - Springer
Background Liver metastasis is the leading cause of death in patients with colorectal cancer
(CRC). Surgical resection of the liver metastases increases the incidence of long-term …

Renalase attenuates mouse fatty liver ischemia/reperfusion injury through mitigating oxidative stress and mitochondrial damage via activating SIRT1

T Zhang, J Gu, J Guo, K Chen, H Li… - Oxidative Medicine and …, 2019 - Wiley Online Library
Liver ischemia/reperfusion (IR) injury is a severe complication of liver surgery. Moreover,
nonalcoholic fatty liver disease (NAFLD) patients are particularly vulnerable to IR injury, with …

[HTML][HTML] TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway

S Li, Z Yi, M Deng, MJ Scott, C Yang, W Li, Z Lei… - JCI insight, 2019 - ncbi.nlm.nih.gov
Thymic stromal lymphopoietin (TSLP) is a cytokine mainly released by epithelial cells that
plays important roles in inflammation, autoimmune disease, and cancer. While TSLP is …

Protective role of mTOR in liver ischemia/reperfusion injury: involvement of inflammation and autophagy

T Zhang, J Guo, J Gu, K Chen, H Li… - Oxidative Medicine and …, 2019 - Wiley Online Library
Liver ischemia/reperfusion (IR) injury is a common phenomenon after liver resection and
transplantation, which often results in liver graft dysfunction such as delayed graft function …