Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4‐hydroxy‐2‐nonenal

A Ayala, MF Muñoz, S Argüelles - Oxidative medicine and …, 2014 - Wiley Online Library
Lipid peroxidation can be described generally as a process under which oxidants such as
free radicals attack lipids containing carbon‐carbon double bond (s), especially …

Oxidative stress and redox regulation of lung inflammation in COPD

I Rahman, IM Adcock - European respiratory journal, 2006 - Eur Respiratory Soc
Reactive oxygen species, either directly or via the formation of lipid peroxidation products,
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …

Cellular glutathione and thiols metabolism

DA Dickinson, HJ Forman - Biochemical pharmacology, 2002 - Elsevier
Low molecular weight thiol-containing compounds have an essential role in many
biochemical and pharmacological reactions due to the ease with each they are oxidized …

Oxidative stress and cell signalling

G Poli, G Leonarduzzi, F Biasi… - Current medicinal …, 2004 - ingentaconnect.com
An increasing body of evidence from animal models, human specimens and cell lines points
to reactive oxygen species as likely involved in the pathways, which convey both …

Glutathione in defense and signaling: lessons from a small thiol

DA Dickinson, HJ Forman - Annals of the New York Academy of …, 2002 - Wiley Online Library
The mechanisms of thiol metabolism and chemistry have particular relevance to both
cellular defenses against toxicant exposure and to redox signaling. Here, we will focus on …

4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease

I Rahman, AAM van Schadewijk… - American journal of …, 2002 - atsjournals.org
Cigarette smoking results in oxidative stress and inflammation in the lungs, which are
involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). 4-Hydroxy-2 …

4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interest

G Poli, RJ Schaur, WG Siems… - Medicinal research …, 2008 - Wiley Online Library
A comprehensive focus on 4‐hydroxynonenal (HNE) as candidate molecule in a variety of
pathophysiological conditions occurring in humans is here provided. Despite an active, now …

Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-κB and pro-inflammatory gene expression

I Rahman, J Marwick, P Kirkham - Biochemical pharmacology, 2004 - Elsevier
Reactive oxygen species (ROS), either directly or via the formation of lipid peroxidation
products, such as 4-hydroxy-2-nonenal, acrolein and F2-isoprostanes, may play a role in …

Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein

MK Kwak, TW Kensler, RA Casero Jr - Biochemical and biophysical …, 2003 - Elsevier
The naturally occurring polycationic polyamines including putrescine, spermidine, and
spermine play an important role in cell growth, differentiation, and gene expression …

Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases.

I Rahman - Journal of biochemistry and molecular biology, 2003 - europepmc.org
Inflammatory lung diseases are characterized by chronic inflammation and
oxidant/antioxidant imbalance. The sources of the increased oxidative stress in patients with …