Generation of nanoscopic membrane curvature for membrane trafficking

MM Kozlov, JW Taraska - Nature reviews Molecular cell biology, 2023 - nature.com
Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Molecular shape solution for mesoscopic remodeling of cellular membranes

PV Bashkirov, PI Kuzmin, J Vera Lillo… - Annual review of …, 2022 - annualreviews.org
Cellular membranes self-assemble from and interact with various molecular species. Each
molecule locally shapes the lipid bilayer, the soft elastic core of cellular membranes. The …

Molecular architecture of the human caveolin-1 complex

JC Porta, B Han, A Gulsevin, JM Chung, Y Peskova… - Science …, 2022 - science.org
Membrane-sculpting proteins shape the morphology of cell membranes and facilitate
remodeling in response to physiological and environmental cues. Complexes of the …

Bacterial lipid biophysics and membrane organization

LMY Mitchison-Field, BJ Belin - Current Opinion in Microbiology, 2023 - Elsevier
The formation of lateral microdomains is emerging as a central organizing principle in
bacterial membranes. These microdomains are targets of antibiotic development and have …

Application of computational approaches in biomembranes: From structure to function

J Guo, Y Bao, M Li, S Li, L Xi, P Xin… - Wiley …, 2023 - Wiley Online Library
Biological membranes (biomembranes) are one of the most complicated structures that
allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing …

Insights into membrane curvature sensing and membrane remodeling by intrinsically disordered proteins and protein regions

C Has, P Sivadas, SL Das - The Journal of Membrane Biology, 2022 - Springer
Cellular membranes are highly dynamic in shape. They can rapidly and precisely regulate
their shape to perform various cellular functions. The protein's ability to sense membrane …

Molecular dynamics simulations of curved lipid membranes

AH Larsen - International Journal of Molecular Sciences, 2022 - mdpi.com
Eukaryotic cells contain membranes with various curvatures, from the near-plane plasma
membrane to the highly curved membranes of organelles, vesicles, and membrane …

Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling?

AK Samhan-Arias, J Poejo, D Marques-da-Silva… - Molecules, 2023 - mdpi.com
Lipid membrane nanodomains or lipid rafts are 10–200 nm diameter size cholesterol-and
sphingolipid-enriched domains of the plasma membrane, gathering many proteins with …

Phospholipid membranes as chemically and functionally tunable materials

D Huster, S Maiti, A Herrmann - Advanced Materials, 2024 - Wiley Online Library
The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes.
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …

The Role of Cholesterol in M2 Clustering and Viral Budding Explained

D Kolokouris, IE Kalenderoglou… - Journal of Chemical …, 2024 - ACS Publications
The influenza A M2 homotetrameric channel consists of four transmembrane (TM) and four
amphipathic helices (AHs). This viral proton channel is suggested to form clusters in the …