Sepsis is a major cause of morbidity and mortality worldwide. Sepsis-associated coagulation
disorders are involved in the pathogenesis of multiorgan failure and lead to a subsequently …

Megakaryocytes (MKs) are large cells giving rise to platelets. It is well established that in
adults, MKs develop from hematopoietic stem cells and reside in the bone marrow. MKs are …

Emerging evidence has revealed a direct differentiation route from hematopoietic stem cells
to megakaryocytes (direct route), in addition to the classical differentiation route through a …

Despite increased understanding of the genomic landscape of Myeloproliferative
Neoplasms (MPNs), the pathological mechanisms underlying abnormal megakaryocyte (Mk) …

Megakaryocytes (Mks) in bone marrow are heterogeneous in terms of polyploidy. They not
only produce platelets but also support the self-renewal of hematopoietic stem cells and …

A state of the art lecture titled “Megakaryocytes in the Lung” was presented at the London
International Society on Thrombosis and Haemostasis congress in 2022. This lecture …

The skin's recognised functions may undergo physiological alterations due to ageing,
manifesting as varying degrees of facial wrinkles, diminished tautness, density, and volume …

A key step in platelet production is the migration of megakaryocytes to the vascular
sinusoids within the bone marrow. This homing is mediated by the chemokine CXCL12 and …

Implant-associated infection (IAI) is a prevalent and potentially fatal complication of
orthopaedic surgery. Boosting antibacterial immunity, particularly the macrophage-mediated …

Platelets are non-nucleated mammalian cells originating from the cytoplasmic expulsion of
the megakaryocytes. Megakaryocytes develop during hematopoiesis through …