SUMO-mediated regulation of DNA damage repair and responses
P Sarangi, X Zhao - Trends in biochemical sciences, 2015 - cell.com
Sumoylation has important roles during DNA damage repair and responses. Recent broad-
scope and substrate-based studies have shed light on the regulation and significance of …
scope and substrate-based studies have shed light on the regulation and significance of …
[HTML][HTML] SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane
The membrane association of the tumour suppressor phosphatase and tensin homologue
(PTEN) is required to oppose the phosphatidylinositol-3-kinase/AKT pathway by …
(PTEN) is required to oppose the phosphatidylinositol-3-kinase/AKT pathway by …
Two-way communications between ubiquitin-like modifiers and DNA
HD Ulrich - Nature structural & molecular biology, 2014 - nature.com
Many aspects of nucleic acid metabolism, such as DNA replication, repair and transcription,
are regulated by the post-translational modifiers ubiquitin and SUMO. Not surprisingly, DNA …
are regulated by the post-translational modifiers ubiquitin and SUMO. Not surprisingly, DNA …
[HTML][HTML] Olig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting
H Liu, W Weng, R Guo, J Zhou, J Xue… - Cell Death & …, 2020 - nature.com
Posttranslational modifications of nuclear proteins, including transcription factors, nuclear
receptors, and their coregulators, have attracted much attention in cancer research …
receptors, and their coregulators, have attracted much attention in cancer research …
Identification of a noncanonical RNA binding domain in the U2 snRNP protein SF3A1
W Martelly, B Fellows, K Senior, T Marlowe, S Sharma - Rna, 2019 - rnajournal.cshlp.org
During splicing of pre-mRNA, 5′ and 3′ splice sites are brought within proximity by
interactions between the pre-mRNA bound U1 and U2 snRNPs, followed by recruitment of …
interactions between the pre-mRNA bound U1 and U2 snRNPs, followed by recruitment of …
[HTML][HTML] SUMO-1 regulates the conformational dynamics of thymine-DNA glycosylase regulatory domain and competes with its DNA binding activity
Background The human thymine-DNA glycosylase (TDG) plays a dual role in base excision
repair of G: U/T mismatches and in transcription. Regulation of TDG activity by SUMO-1 …
repair of G: U/T mismatches and in transcription. Regulation of TDG activity by SUMO-1 …
A TDG/CBP/RARα ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes
H Léger, C Smet-Nocca… - Genomics …, 2014 - academic.oup.com
The thymine DNA glycosylase (TDG) is a multifunctional enzyme, which is essential for
embryonic development. It mediates the base excision repair (BER) of G: T and G: U DNA …
embryonic development. It mediates the base excision repair (BER) of G: T and G: U DNA …
Sumoylation of Cas9 at lysine 848 regulates protein stability and DNA binding
CRISPR/Cas9 is a popular genome editing technology. Although widely used, little is known
about how this prokaryotic system behaves in humans. An unwanted consequence of …
about how this prokaryotic system behaves in humans. An unwanted consequence of …
Bioinformatic analysis of Msx1 and Msx2 involved in craniofacial development
J Dai, Z Mou, S Shen, Y Dong, T Yang… - Journal of Craniofacial …, 2014 - journals.lww.com
Msx1 and Msx2 were revealed to be candidate genes for some craniofacial deformities,
such as cleft lip with/without cleft palate (CL/P) and craniosynostosis. Many other genes …
such as cleft lip with/without cleft palate (CL/P) and craniosynostosis. Many other genes …
[HTML][HTML] Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1
Human ubiquitin ligase HERC2, a component of the DNA repair machinery, has been linked
to neurological diseases and cancer. Here, we show that the ZZ domain of HERC2 (HERC2 …
to neurological diseases and cancer. Here, we show that the ZZ domain of HERC2 (HERC2 …