Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

Plasmacytoid dendritic cells (pDCs) represent a unique cell type within the innate immune
system. Their defining property is the recognition of pathogen-derived nucleic acids through …

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines
underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare …

SARS-CoV-2 infection induces the generation of virus-specific CD4+ and CD8+ effector and
memory T cells. However, the contribution of T cells in controlling SARS-CoV-2 during …

The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and
transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) …

SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key
role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill …

Type I and type III interferons are among the most potent anti-viral cytokines produced by the
immune system. The recent outbreak of SARS-CoV-2, which causes COVID-19 …

Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity.
DCs have been historically considered as the most effective and potent cell population to …

Type I and III interferons (IFNs) are essential for antiviral immunity and act through two
different but complimentary pathways. First, IFNs activate intracellular antimicrobial …

Highlights•Sensing of pathogen, and mislocalised host, nucleic acid triggers IFN
induction.•Signalling pathways eliciting IFN-I and IFN-III are regulated at multiple …