Mimicking the brain: Epstein-Barr virus and foreign agents as drivers of neuroimmune attack in multiple sclerosis
OG Thomas, T Olsson - Frontiers in Immunology, 2023 - frontiersin.org
T cells have an essential role in adaptive immunity against pathogens and cancer, but
failure of thymic tolerance mechanisms can instead lead to escape of T cells with the ability …
failure of thymic tolerance mechanisms can instead lead to escape of T cells with the ability …
Mechanisms of sex hormones in autoimmunity: focus on EAE
Sex-related differences in the occurrence of autoimmune diseases is well documented, with
females showing a greater propensity to develop these diseases than their male …
females showing a greater propensity to develop these diseases than their male …
Geographical variations in sex ratio trends over time in multiple sclerosis
Background A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients
was demonstrated in many countries around the world. So far, a direct comparison of sex …
was demonstrated in many countries around the world. So far, a direct comparison of sex …
Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It's complicated
PA McCombe, JM Greer - Frontiers in Immunology, 2022 - frontiersin.org
Experimental autoimmune encephalomyelitis (EAE) can be induced in many animal strains
by inoculation with central nervous system antigens and adjuvant or by the passive transfer …
by inoculation with central nervous system antigens and adjuvant or by the passive transfer …
Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-α-reactive CD4 T cells in A/J mice
Enteroviruses like coxsackievirus B3 (CVB3) are common suspects in myocarditis/dilated
cardiomyopathy patients. Autoimmunity has been proposed as an underlying mechanism …
cardiomyopathy patients. Autoimmunity has been proposed as an underlying mechanism …
Viral myocarditis involves the generation of autoreactive T cells with multiple antigen specificities that localize in lymphoid and non-lymphoid organs in the mouse …
RH Basavalingappa, R Arumugam, N Lasrado… - Molecular …, 2020 - Elsevier
Autoreactive T cells may contribute to post-viral myocarditis induced with Coxsackievirus B3
(CVB3), but the underlying mechanisms of their generation are unclear. Here, we have …
(CVB3), but the underlying mechanisms of their generation are unclear. Here, we have …
Identification of novel mimicry epitopes for cardiac myosin heavy chain-α that induce autoimmune myocarditis in A/J mice
Myocarditis is one cause of sudden cardiac death in young adolescents, and individuals
affected with myocarditis can develop dilated cardiomyopathy, a frequent reason for heart …
affected with myocarditis can develop dilated cardiomyopathy, a frequent reason for heart …
Detection of autoreactive CD4 T cells using major histocompatibility complex class II dextramers
Background Tetramers are useful tools to enumerate the frequencies of antigen-specific T
cells. However, unlike CD8 T cells, CD4 T cells-especially self-reactive cells-are challenging …
cells. However, unlike CD8 T cells, CD4 T cells-especially self-reactive cells-are challenging …
Immune cell contributors to the female sex bias in multiple sclerosis and experimental autoimmune encephalomyelitis
N Alvarez-Sanchez, SE Dunn - Sex Differences in Brain Function and …, 2022 - Springer
Multiple sclerosis (MS) is a chronic, autoimmune, demyelinating disease of the central
nervous system (CNS) that leads to axonal damage and accumulation of disability …
nervous system (CNS) that leads to axonal damage and accumulation of disability …
Identification of immunogenic epitopes that permit the detection of antigen-specific T cell responses in multiple serotypes of group B coxsackievirus infections
N Lasrado, A Gangaplara, R Arumugam… - Viruses, 2020 - mdpi.com
Coxsackievirus group B (CVB) contains six serotypes that can affect various organs. Some
of these organ-specific diseases such as myocarditis and pancreatitis can be caused by …
of these organ-specific diseases such as myocarditis and pancreatitis can be caused by …