The neurotrophic tyrosine receptor kinase (NTRK) gene family encodes three tropomyosin
receptor kinases (TRKA, TRKB, TRKC) that contribute to central and peripheral nervous …

A recent breakthrough in the classification of soft tissue tumors (STT) has been a significant
expansion in the number of neoplasms associated with NTRK and other kinase related …

Chromosomal translocations involving the NTRK1, NTRK2, and NTRK3 genes (TRK
fusions), which encode the neurotrophin tyrosine kinase receptors TRKA, TRKB, and TRKC …

A major breakthrough in the classification of soft tissue tumors has been the recent
identification of NTRK-fusion related neoplasms which are amenable to highly effective …

Kinase alterations are increasingly recognised as oncogenic drivers in mesenchymal
tumours. Infantile fibrosarcoma and the related renal tumour, congenital mesoblastic …

Infantile fibrosarcoma (IFS)/cellular congenital mesoblastic nephroma (cCMN) commonly
harbors the classic ETV6-NTRK3 translocation. However, there are recent reports of …

Targeted neurotrophic tropomyosin receptor kinase (TRK) inhibitors offer a highly specific
therapeutic option for patients with infantile fibrosarcoma (IFS) carrying the NTRK gene …

Small tandem duplications of DNA occur frequently in the human genome and are
implicated in the aetiology of certain human cancers. Recent studies have suggested that …

Fibroblastic and myofibroblastic neoplasms of the head and neck encompass a group of
rare tumor types with often overlapping clinicopathologic features that range in biologic …

Aims The classification of paediatric spindle mesenchymal tumours is evolving, and the
spectrum of so‐called 'infantile fibrosarcoma'has expanded to include tumours with NTRK …