High‐aspect‐ratio nanostructured surfaces as biological metamaterials

SG Higgins, M Becce… - Advanced …, 2020 - Wiley Online Library
Materials patterned with high‐aspect‐ratio nanostructures have features on similar length
scales to cellular components. These surfaces are an extreme topography on the cellular …

Application of FRET biosensors in mechanobiology and mechanopharmacological screening

L Liu, F He, Y Yu, Y Wang - Frontiers in Bioengineering and …, 2020 - frontiersin.org
Extensive studies have shown that cells can sense and modulate the biomechanical
properties of the ECM within their resident microenvironment. Thus, targeting the …

Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues

D Pham, X Tan, B Balderson, J Xu, LF Grice… - Nature …, 2023 - nature.com
Spatial transcriptomics (ST) technologies generate multiple data types from biological
samples, namely gene expression, physical distance between data points, and/or tissue …

stLearn: integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues

D Pham, X Tan, J Xu, LF Grice, PY Lam, A Raghubar… - BioRxiv, 2020 - biorxiv.org
Spatial Transcriptomics is an emerging technology that adds spatial dimensionality and
tissue morphology to the genome-wide transcriptional profile of cells in an undissociated …

Evaluating batch correction methods for image-based cell profiling

J Arevalo, E Su, JD Ewald, R van Dijk… - Nature …, 2024 - nature.com
High-throughput image-based profiling platforms are powerful technologies capable of
collecting data from billions of cells exposed to thousands of perturbations in a time-and cost …

Delivering mechanical stimulation to cells: state of the art in materials and devices design

Y Zhang, P Habibovic - Advanced Materials, 2022 - Wiley Online Library
Biochemical signals, such as growth factors, cytokines, and transcription factors are known
to play a crucial role in regulating a variety of cellular activities as well as maintaining the …

Emerging roles of 1D vertical nanostructures in orchestrating immune cell functions

Y Chen, J Wang, X Li, N Hu, NH Voelcker… - Advanced …, 2020 - Wiley Online Library
Engineered nano–bio cellular interfaces driven by 1D vertical nanostructures (1D‐VNS) are
set to prompt radical progress in modulating cellular processes at the nanoscale. Here …

[HTML][HTML] Modification of the surface nanotopography of implant devices: A translational perspective

K Harawaza, B Cousins, P Roach, A Fernandez - Materials Today Bio, 2021 - Elsevier
There is an increasing need for the development of superior, safe, and more sophisticated
implants, especially as our society historically has been moving towards an increasingly …

Hierarchically assembled nanofiber scaffold guides long bone regeneration by promoting osteogenic/chondrogenic differentiation of endogenous mesenchymal stem …

H Pan, Y Wei, C Zeng, G Yang, C Dong, W Wan… - Small, 2024 - Wiley Online Library
Critical‐sized segmental long bone defects represent a challenging clinical dilemma in the
management of battlefield and trauma‐related injuries. The residual bone marrow cavity of …

The future of bone regeneration: integrating AI into tissue engineering

BS Mackay, K Marshall, JA Grant-Jacob… - Biomedical Physics …, 2021 - iopscience.iop.org
Tissue engineering is a branch of regenerative medicine that harnesses biomaterial and
stem cell research to utilise the body's natural healing responses to regenerate tissue and …