O-linked β-DN-acetylglucosamine (O-GlcNAc), as a posttranslational modification (PTM), is
a reversible reaction that attaches β-N-GlcNAc to Ser/Thr residues on specific proteins by O …

Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed
and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our …

Tumor-associated carbohydrate antigens (TACAs) support cell survival that could be
interrupted by anti-TACA antibodies. Among TACAs that mediate cell survival signals are the …

The cell surface is covered by a dense layer of protein-and lipid-linked glycans. Although it
has been known that distinct glycan structures are associated with cancer, the whole …

Carbohydrate epitopes or glycotopes are structurally diverse, occur in a variety of chemical
contexts, and are present on the surfaces of cells in the body and on the surfaces of …

Breast cancer patients diagnosed with HR+/HER2–tumors face a persistent risk of distant
recurrence long after completion of their treatment. Strategies to induce anti-tumor immune …

Introduction Because of its restricted distribution in normal tissues and its high expression on
tumors of neuroectodermal origin, GD2 ganglioside is an excellent target for active specific …

Dickkopf-1 (DKK1) is an ideal target for the immunotherapy of multiple myeloma. Heat Shock
protein70 (HSP70) is a class of important molecular chaperone to promote antigen …

The immune system responds efficiently to bacteria, viruses and other agents however, the
immune response to cancers is not as effective. In most cases other than specific genetic …

The dynamic and reversible modification of nuclear and cytoplasmic proteins by O-
GlcNAcylation significantly impacts the function and dysfunction of the immune system. O …