Since the first high-resolution structure of the nucleosome was reported in 1997, the
available information on chromatin structure has increased very rapidly. Here, we review …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Histone lysine methylations have primarily been linked to selective recruitment of reader or
effector proteins that subsequently modify chromatin regions and mediate genome functions …

The core histone tails are critical in chromatin structure and signaling. Studies over the past
several decades have provided a wealth of information on the histone tails and their …

1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …

Many amyloid fibrils associated with neurodegenerative diseases consist of an ordered fibril
core (FC) and disordered terminal regions (TRs). The former represents a stable scaffold …

Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate
DNA processes, including transcription, replication, and repair. Conformational dynamics …

Unconstrained atomistic simulations of intrinsically disordered proteins and peptides (IDP)
remain a challenge: widely used,“general purpose” water models tend to favor overly …

Histone tails and their epigenetic modifications play crucial roles in gene expression
regulation by altering the architecture of chromatin. However, the structural mechanisms by …

An octamer of histone proteins wraps about 200 bp of DNA into two superhelical turns to
form nucleosomes found in chromatin. Although the static structure of the nucleosomal core …