Pharmacogenomics: driving personalized medicine
Personalized medicine tailors therapies, disease prevention, and health maintenance to the
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …
Neuroendocrine neoplasms of the lung and gastrointestinal system: convergent biology and a path to better therapies
K Kawasaki, N Rekhtman… - Nature Reviews …, 2023 - nature.com
Neuroendocrine neoplasms (NENs) can develop in almost any organ and span a spectrum
from well-differentiated and indolent neuroendocrine tumours (NETs) to poorly differentiated …
from well-differentiated and indolent neuroendocrine tumours (NETs) to poorly differentiated …
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
Molecular biomarkers of disease outcomes and mechanisms of acquired resistance to first-line osimertinib in advanced EGFR-mutant lung cancers
Introduction Preferred first-line treatment for patients with metastatic EGFR-mutant lung
cancer is osimertinib, yet it is not known whether patient outcomes may be improved by …
cancer is osimertinib, yet it is not known whether patient outcomes may be improved by …
Molecular characterization of endometrial carcinomas in Black and White patients reveals disparate drivers with therapeutic implications
B Weigelt, A Marra, P Selenica, E Rios-Doria… - Cancer discovery, 2023 - AACR
Although the incidence of endometrial carcinoma (EC) is similar in Black and White women,
racial disparities are stark, with the highest mortality rates observed among Black patients …
racial disparities are stark, with the highest mortality rates observed among Black patients …
Automated real-world data integration improves cancer outcome prediction
The digitization of health records and growing availability of tumour DNA sequencing
provide an opportunity to study the determinants of cancer outcomes with unprecedented …
provide an opportunity to study the determinants of cancer outcomes with unprecedented …
Genomic profiling reveals germline predisposition and homologous recombination deficiency in pancreatic acinar cell carcinoma
D Mandelker, A Marra, B Zheng-Lin… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE To determine the genetic predisposition underlying pancreatic acinar cell
carcinoma (PACC) and characterize its genomic features. METHODS Both somatic and …
carcinoma (PACC) and characterize its genomic features. METHODS Both somatic and …
Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?
This study describes “lobular-like invasive mammary carcinomas”(LLIMCas), a group of low-
to intermediate-grade invasive mammary carcinomas with discohesive, diffusely infiltrative …
to intermediate-grade invasive mammary carcinomas with discohesive, diffusely infiltrative …
Lineage-specific intolerance to oncogenic drivers restricts histological transformation
Lung adenocarcinoma (LUAD) and small cell lung cancer (SCLC) are thought to originate
from different epithelial cell types in the lung. Intriguingly, LUAD can histologically transform …
from different epithelial cell types in the lung. Intriguingly, LUAD can histologically transform …
Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations
Abstract CDH1 (E-cadherin) bi-allelic inactivation is the hallmark alteration of breast invasive
lobular carcinoma (ILC), resulting in its discohesive phenotype. A subset of ILCs, however …
lobular carcinoma (ILC), resulting in its discohesive phenotype. A subset of ILCs, however …