Salmonellae are important causes of enteric diseases in all vertebrates. Characterization of
the molecular mechanisms that underpin the interactions of salmonellae with their animal …

Salmonella pathogenesis is dependent on its ability to invade and replicate within host cells.
Following invasion the bacteria remain within a modified phagosome known as the …

In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and
scar formation. We hypothesized that macrophages undergo polarization state changes over …

Nascent phagosomes must undergo a series of fusion and fission reactions to acquire the
microbicidal properties required for the innate immune response. Here we demonstrate that …

Escherichia coli is one of the leading causes of bovine mastitis; it can cause sub-clinical,
and clinical mastitis characterized by systemic changes, abnormal appearance of milk, and …

The Arabidopsis genome sequence reveals that gene families such as the Rab GTPase
family, which encodes key determinants of vesicle-targeting specificity, are considerably …

Aspergillus fumigatus is the most prevalent airborne fungal pathogen responsible for fatal
invasive aspergillosis in immunocompromised patients. Upon arrival in the lung alveolus …

Salmonella typhimurium requires a type III secretion system encoded by pathogenicity
island (SPI)-2 to survive and proliferate within macrophages. This survival implies that S …

Salmonella enterica serovar Typhimurium (S. typhimurium) is a gram‐negative facultative
intracellular pathogen that can infect a broad range of mammalian hosts. Following invasion …

Intracellular bacterial pathogens have evolved highly specialized mechanisms to enter and
survive within their eukaryotic hosts. In order to do this, bacterial pathogens need to avoid …