Human metabolites of cannabidiol: a review on their formation, biological activity, and relevance in therapy

I Ujváry, L Hanuš - Cannabis and cannabinoid research, 2016 - liebertpub.com
Cannabidiol (CBD), the main nonpsychoactive constituent of Cannabis sativa, has shown a
wide range of therapeutically promising pharmacological effects either as a sole drug or in …

Hexahydrocannabinol and closely related semi‐synthetic cannabinoids: A comprehensive review

I Ujváry - Drug testing and analysis, 2024 - Wiley Online Library
Since the early 2000s, there has been a turmoil on the global illicit cannabinoid market.
Parallel to legislative changes in some jurisdictions regarding herbal cannabis, unregulated …

Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review

SM Stout, NM Cimino - Drug metabolism reviews, 2014 - Taylor & Francis
Exogenous cannabinoids are structurally and pharmacologically diverse compounds that
are widely used. The purpose of this systematic review is to summarize the data …

Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly

R Abuhasira, LBL Schleider, R Mechoulam… - European journal of …, 2018 - Elsevier
Introduction There is a substantial growth in the use of medical cannabis in recent years and
with the aging of the population, medical cannabis is increasingly used by the elderly. We …

Pharmacokinetic drug interactions with tobacco, cannabinoids and smoking cessation products

GD Anderson, LN Chan - Clinical pharmacokinetics, 2016 - Springer
Tobacco smoke contains a large number of compounds in the form of metals, volatile gases
and insoluble particles, as well as nicotine, a highly addictive alkaloid. Marijuana is the most …

Multigenerational and transgenerational inheritance of drug exposure: the effects of alcohol, opiates, cocaine, marijuana, and nicotine

NL Yohn, MS Bartolomei, JA Blendy - Progress in biophysics and molecular …, 2015 - Elsevier
Familial inheritance of drug abuse is composed of both genetic and environmental factors.
Additionally, epigenetic transgenerational inheritance may provide a means by which …

Cannabis and cannabinoids: kinetics and interactions

BC Foster, H Abramovici, CS Harris - The American journal of medicine, 2019 - Elsevier
Cannabis sativa and related products are widely used, but their potential to cause significant
clinical interactions remains unclear, particularly for cannabinoid-enriched or otherwise …

Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development

SF Zhou, ZW Zhou, LP Yang… - Current medicinal …, 2009 - ingentaconnect.com
Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …

A marijuana-drug interaction primer: precipitants, pharmacology, and pharmacokinetics

EJ Cox, N Maharao, G Patilea-Vrana… - Pharmacology & …, 2019 - Elsevier
Abstract In the United States, the evolving landscape of state-legal marijuana use for
recreational and/or medical purposes has given rise to flourishing markets for marijuana and …

[图书][B] Human drug metabolism

MD Coleman - 2020 - books.google.com
Provides a timely update to a key textbook on human drug metabolism The third edition of
this comprehensive book covers basic concepts of teaching drug metabolism, starting from …