The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

In the last ten years, there has been a dramatic surge in the number of publications where
single or groups of cells are grown in substrata that have elements of basement membrane …

Human induced pluripotent stem cells (hiPSCs,,) are useful in disease modeling and drug
discovery, and they promise to provide a new generation of cell-based therapeutics. To date …

The ectopic expression of transcription factors can reprogram cell fate, yet it is unknown how
the initial binding of factors to the genome relates functionally to the binding seen in the …

Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in
obtaining live neurons from patients and the inability to model the sporadic form of the …

Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …

The ability to model human brain development in vitro represents an important step in our
study of developmental processes and neurological disorders. Protocols that utilize human …

Current organoid models are limited by their inability to mimic mature organ architecture and
associated tissue microenvironments,. Here we create multilayer bladder 'assembloids' by …

Human induced pluripotent stem cells (iPSCs) have been generated with varied efficiencies
from multiple tissues. Yet, acquiring donor cells is, in most instances, an invasive procedure …

The conversion of lineage-committed cells to induced pluripotent stem cells (iPSCs) by
reprogramming is accompanied by a global remodeling of the epigenome,,,,, resulting in …