Acute myeloid leukemia (AML) is a malignant disorder of the bone marrow which is
characterized by the clonal expansion and differentiation arrest of myeloid progenitor cells …

Natural killer (NK) cells are part of the innate immune defense against infection and cancer
and are especially useful in combating certain viral pathogens. The utility of NK cells in …

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines
underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare …

Germline GATA2 mutations cause cellular deficiencies with high propensity for myeloid
disease. We investigated 426 children and adolescents with primary myelodysplastic …

Severe influenza disease strikes otherwise healthy children and remains unexplained. We
report compound heterozygous null mutations in IRF7, which encodes the transcription …

Haploinsufficiency of the hematopoietic transcription factor GATA2 underlies monocytopenia
and mycobacterial infections; dendritic cell, monocyte, B, and natural killer (NK) lymphoid …

Myelodysplasia is a diagnostic feature of myelodysplastic syndromes (MDSs) but is also
found in other myeloid neoplasms. Its molecular basis has been recently elucidated by …

Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN immunity and
underlie severe influenza pneumonitis. We report three unrelated children with influenza A …

Life-threatening pulmonary influenza can be caused by inborn errors of type I and III IFN
immunity. We report a 5-yr-old child with severe pulmonary influenza at 2 yr. She is …

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of
childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in …