Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
BF Haynes, K Wiehe, P Borrow, KO Saunders… - Nature Reviews …, 2023 - nature.com
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive.
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
A central goal of HIV-1 vaccine research is the elicitation of antibodies capable of
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G
Summary The HIV-1-envelope (Env) trimer is covered by a glycan shield of∼ 90 N-linked
oligosaccharides, which comprises roughly half its mass and is a key component of HIV …
oligosaccharides, which comprises roughly half its mass and is a key component of HIV …
Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice
A vaccine that elicits broadly neutralizing antibodies (bNAbs) against HIV-1 is likely to be
protective, but this has not been achieved. To explore immunization regimens that might …
protective, but this has not been achieved. To explore immunization regimens that might …
[HTML][HTML] Vaccine-induced antibodies that neutralize group 1 and group 2 influenza A viruses
Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a
universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza …
universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza …
HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies
Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope
(Env) trimer are the most common bnAbs induced during infection, making them promising …
(Env) trimer are the most common bnAbs induced during infection, making them promising …
A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure
Broadly neutralizing antibodies (bnAbs) to HIV delineate vaccine targets and are
prophylactic and therapeutic agents. Some of the most potent bnAbs target a quaternary …
prophylactic and therapeutic agents. Some of the most potent bnAbs target a quaternary …
Native‐like Env trimers as a platform for HIV‐1 vaccine design
RW Sanders, JP Moore - Immunological reviews, 2017 - Wiley Online Library
We describe the development and potential use of various designs of recombinant HIV‐1
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …
Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies
Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine
development. VRC01-class bnAbs are important vaccine leads because their precursor B …
development. VRC01-class bnAbs are important vaccine leads because their precursor B …