Background: Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory
drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been …

Objective: Topical delivery of drugs is an alternative to oral administration, often with similar
efficacy but potentially a more favorable tolerability profile. However, topical formulations …

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Background: Osteoarthritis (OA) and cardiovascular disease (CVD) share age and obesity
as risk factors, but may also be linked by pathogenic mechanisms involving metabolic …

Pain Assessment and Pharmacologic Management, by highly renowned authors Chris
Pasero and Margo McCaffery, is destined to become the definitive resource in pain …

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in infants, children, and
adolescents worldwide; however, despite sufficient evidence of the beneficial effects of …

While topical non-steroidal anti-inflammatory drugs are considered safe, their long-term
efficacy for osteoarthritis has been suspect. We conducted a 12-week, double-blind, double …

Systemic bioavailability and pharmacodynamics of topical diclofenac sodium gel 1% were
compared with those of oral diclofenac sodium 50‐mg tablets. In a randomized, 3‐way …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of pain
associated with a variety of indications, including arthritic conditions, but their usefulness is …

Objective. To systematically review the literature on reported adverse effects (AE) associated
with use of topical nonsteroidal antiinflammatory drugs (NSAID) in older adults with …