The diverse repertoire of antibodies or immunoglobulins (Igs) in the immune system is
created by B lymphocytes. The specificity of an lg for an antigen is made up by three …

Abstract Interleukin‐5 (IL‐5) is an interdigitating homodimeric glycoprotein that is initially
identified by its ability to support the in vitro growth and differentiation of mouse B cells and …

NEW-the leading book in its field now fully updated andrevised! Click here to access two
FREE sample chapters! An Essential resource for all hematologists, oncologists …

Osteoclasts differentiate from the hemopoietic monocyte/macrophage cell lineage in bone
marrow through cell-cell interactions between osteoclast progenitors and …

We generated interleukin-5 receptor α chain (IL-5Rα)–deficient (IL-5Rα−/−) mice by gene
targeting. The IL-5Rα−/− mice showed decreased numbers of B-1 cells concomitant with low …

According to the current model of adult hematopoiesis, differentiation of pluripotential
hematopoietic stem cells into common myeloid-and lymphoid-committed progenitors …

Publisher Summary The chapter summarizes advances in interleukin-5 (IL-5) and IL-soluble
receptor (IL-SR) research in the study of structure, physiologic functions, and the unique …

Human interleukin 5 (IL-5) plays an important role in proliferation and differentiation of
human eosinophils. We report the isolation of cDNA clones from cDNA libraries of human …

At least three B cell subsets, B-1a, B-1b and B-2, or conventional B cells are present in the
mouse periphery. Here we demonstrate that B-1 cells spontaneously proliferate in stationary …

Interleukin-5 (IL-5) stimulates proliferation and differentiation of B cells and eosinophils. IL-5
receptor (IL-5R) comprises α and βc chains. IL-5 specifically binds to IL-5Rα and induces the …