Targeting epigenetic regulators to overcome drug resistance in cancers

N Wang, T Ma, B Yu - Signal transduction and targeted therapy, 2023 - nature.com
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Role of epithelial to mesenchymal transition in colorectal cancer

J Lu, M Kornmann, B Traub - International Journal of Molecular Sciences, 2023 - mdpi.com
The epithelial–mesenchymal transition (EMT) is a cellular reprogramming process that
occurs during embryonic development and adult tissue homeostasis. This process involves …

The lncRNA HOTAIR: a pleiotropic regulator of epithelial cell plasticity

L Amicone, A Marchetti, C Cicchini - Journal of Experimental & Clinical …, 2023 - Springer
The epithelial-to-mesenchymal transition (EMT) is a trans-differentiation process that
endows epithelial cells with mesenchymal properties, including motility and invasion …

Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response

N Ebrahimi, MS Manavi, F Faghihkhorasani… - Cancer and Metastasis …, 2024 - Springer
Epithelial-mesenchymal transition (EMT) is a complicated molecular process that governs
cellular shape and function changes throughout tissue development and embryogenesis. In …

PIWI-interacting RNA-YBX1 inhibits proliferation and metastasis by the MAPK signaling pathway via YBX1 in triple-negative breast cancer

L Wu, S Huang, W Tian, P Liu, Y Xie, Y Qiu, X Li… - Cell Death …, 2024 - nature.com
Breast cancer is the second leading cause of death in women worldwide, with triple-
negative breast cancer (TNBC) having the worst prognosis. Although there are numerous …

lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways

RO Saleh, MTS Al-Ouqaili, E Ali, S Alhajlah… - Medical Oncology, 2024 - Springer
Cancer drug resistance remains a formidable challenge in modern oncology, necessitating
innovative therapeutic strategies. The convergence of intricate regulatory networks involving …

Molecular insights into regulatory RNAs in the cellular machinery

S Yang, SH Kim, E Yang, M Kang, JY Joo - Experimental & Molecular …, 2024 - nature.com
It is apparent that various functional units within the cellular machinery are derived from
RNAs. The evolution of sequencing techniques has resulted in significant insights into …

Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways

H Postwala, Y Shah, PS Parekh, MR Chorawala - Medical Oncology, 2023 - Springer
Colorectal cancer (CRC) is a complex disease characterized by genetic and epigenetic
alterations, playing a crucial role in its development and progression. This review aims to …

Deregulated miRNAs in enzalutamide resistant prostate cancer: A comprehensive review of key molecular alterations and clinical outcomes

I Tavares, M Morais, F Dias, R Medeiros… - Biochimica et Biophysica …, 2023 - Elsevier
Prostate cancer (PC) is the second most frequently diagnosed cancer and the fifth leading
cause of cancer-related deaths in male population worldwide. Since the growth and …

Downregulation of N6-methyladenosine-modified LINC00641 promotes EMT, but provides a ferroptotic vulnerability in lung cancer

S Xi, DJ Ming, JH Zhang, MM Guo, SY Wang… - Cell Death & …, 2023 - nature.com
The prognosis of lung cancer is poor with few effective therapies. Targeting ferroptosis is a
new promising strategy for cancer therapy. LINC00641 has been involved in several …