[HTML][HTML] The cGAS–STING signaling in cardiovascular and metabolic diseases: future novel target option for pharmacotherapy

PK Oduro, X Zheng, J Wei, Y Yang, Y Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
exert essential regulatory function in microbial-and onco-immunology through the induction …

The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications

Z Zhang, Q Huang, D Zhao, F Lian, X Li… - Frontiers in …, 2023 - frontiersin.org
Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia,
with absolute insulin deficiency or insulin resistance as the main cause, and causes damage …

Unraveling the link between mitochondrial dynamics and neuroinflammation

LG de Oliveira, YS Angelo, AH Iglesias… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammatory and neurodegenerative diseases are a major public health problem
worldwide, especially with the increase of life-expectancy observed during the last decades …

[HTML][HTML] Type 2 diabetes mellitus and neurodegenerative disorders: The mitochondrial connection

IR Baduini, JEC Vildosola, S Kavehmoghaddam… - Pharmacological …, 2024 - Elsevier
The incidence of type 2 diabetes mellitus (T2DM) has increased in our society in recent
decades as the population ages, and this trend is not expected to revert. This is the same for …

STING signaling and sterile inflammation

I Couillin, N Riteau - Frontiers in Immunology, 2021 - frontiersin.org
Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely
probe the local environment and maintain host integrity. Besides pathogen recognition …

Mitochondrial dysfunction and oxidative stress in diabetic wound

G Jiang, T Jiang, J Chen, H Yao, R Mao… - … of Biochemical and …, 2023 - Wiley Online Library
Diabetic wounds nowadays have become a major health challenge with the changes of the
disease spectrum. Mitochondria are closely associated with stubborn nonhealing diabetic …

The ideal treatment timing for diabetic retinopathy: the molecular pathological mechanisms underlying early-stage diabetic retinopathy are a matter of concern

WJ Sun, XD An, YH Zhang, XF Zhao, YT Sun… - Frontiers in …, 2023 - frontiersin.org
Diabetic retinopathy (DR) is a prevalent complication of diabetes, significantly impacting
patients' quality of life due to vision loss. No pharmacological therapies are currently …

Effect of high glucose supplementation on pulmonary fibrosis involving reactive oxygen species and TGF-β

W Ning, X Xu, S Zhou, X Wu, H Wu, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
This study explored the profibrotic impact of high glucose in the lung and potential
mechanisms using latent TGF-β1-induced human epithelial cell pulmonary fibrosis and …

DJ-1 regulates mitochondrial function and promotes retinal ganglion cell survival under high glucose-induced oxidative stress

H Peng, H Li, B Ma, X Sun, B Chen - Frontiers in Pharmacology, 2024 - frontiersin.org
Purpose This study aimed to investigate the antioxidative and neuroprotective effects of DJ-1
in mitigating retinal ganglion cell (RGC) damage induced by high glucose (HG). Methods A …

High glucose-induced increasing reactive nitrogen species accumulation triggered mitochondrial dysfunction, inflammation, and apoptosis in keratinocytes

H Rizwan, S Kumar, G Kumari, A Pal - Life Sciences, 2023 - Elsevier
Growing evidence indicates that skin injuries are a common complication of diabetes.
However, the cellular and molecular mechanisms of high glucose (HG) environment trigger …