MicroRNAs and epigenetics

C Moutinho, M Esteller - Advances in cancer research, 2017 - Elsevier
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression mainly at
the posttranscriptional level. Similar to protein-coding genes, their expression is also …

Genetic and epigenetic alterations of micro RNA s and implications for human cancers and other diseases

M Tuna, AS Machado, GA Calin - Genes, Chromosomes and …, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are a well‐studied group of noncoding RNAs that control gene
expression by interacting mainly with messenger RNA. It is known that miRNAs and their …

miR-223 decreases cell proliferation and enhances cell apoptosis in acute myeloid leukemia via targeting FBXW7

Y Xiao, C Su, T Deng - Oncology letters, 2016 - spandidos-publications.com
The expression of microRNA-223 (miR-233) has been investigated in various types of
cancer. However, to the best of our knowledge, the expression and function of miR-223 in …

Transfer RNA detection by small RNA deep sequencing and disease association with myelodysplastic syndromes

Y Guo, A Bosompem, S Mohan, B Erdogan, F Ye… - BMC genomics, 2015 - Springer
Background Although advances in sequencing technologies have popularized the use of
microRNA (miRNA) sequencing (miRNA-seq) for the quantification of miRNA expression …

MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia

W Jiang, J Min, X Sui, Y Qian, Y Liu, Z Liu… - Leukemia & …, 2015 - Taylor & Francis
MicroRNAs (miRNAs) are small RNAs that regulate target gene expression. Using
microarray-based miRNA expression profiling, we compared the miRNA expression in …

The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia

H Karlic, H Herrmann, F Varga, R Thaler… - Critical reviews in …, 2014 - Elsevier
Disordered stem cell epigenetics and apoptosis-regulating mechanisms contribute
essentially to the pathogenesis of myelodysplastic syndromes (MDS) and may trigger …

Deregulated microRNA expression and its pathogenetic implications for myelodysplastic syndromes

X Kuang, J Chi, L Wang - Hematology, 2016 - Taylor & Francis
Objective: Myelodysplastic syndromes (MDS) include a heterogeneous group of clonal
hematological stem cell disorders characterized by ineffective hematopoiesis, cytopenias …

Epigenetic role of miRNAs in normal and leukemic hematopoiesis

F Pagano, E De Marinis, F Grignani, C Nervi - Epigenomics, 2013 - Taylor & Francis
Hematopoiesis is a regulated multistep process, whereby transcriptional and epigenetic
events contribute to progenitor fate determination. miRNAs have emerged as key players in …

[HTML][HTML] miR-378-3p Knockdown recapitulates many of the features of myelodysplastic syndromes

D Wang, M Lin, B Utz, A Bosompem, Y Guo… - The American Journal of …, 2021 - Elsevier
Myelodysplastic syndromes (MDS) are clonal neoplasms of the hematopoietic stem cell that
result in aberrant differentiation of hematopoietic lineages caused by a wide range of …

Analysis of promoter methylation and epigenetic regulation of miR‑32 in colorectal cancer cells

W Wu, S Ye, W Tan, Y Zhou… - Experimental and …, 2019 - spandidos-publications.com
Abstract MicroRNA‑32 (miR‑32) is upregulated in colorectal cancer (CRC) tissues; its
overexpression leads to increased cell proliferation, migration and invasion, as well as …