The emerging roles of deep crypt secretory cells in colonic physiology
MA Schumacher - American Journal of Physiology …, 2023 - journals.physiology.org
Deep crypt secretory (DCS) cells are a population of epithelial cells located at the colonic
crypt base that share some similarities to Paneth and goblet cells. They were initially defined …
crypt base that share some similarities to Paneth and goblet cells. They were initially defined …
The role of Evi/Wntless in exporting Wnt proteins
L Wolf, M Boutros - Development, 2023 - journals.biologists.com
Intercellular communication by Wnt proteins governs many essential processes during
development, tissue homeostasis and disease in all metazoans. Many context-dependent …
development, tissue homeostasis and disease in all metazoans. Many context-dependent …
Multiomics-empowered deep phenotyping of ulcerative colitis identifies biomarker signatures reporting functional remission states
Introduction Ulcerative colitis [UC] is a chronic disease with rising incidence and unclear
aetiology. Deep molecular phenotyping by multiomics analyses may provide novel insights …
aetiology. Deep molecular phenotyping by multiomics analyses may provide novel insights …
Histone deacetylase inhibitor belinostat regulates metabolic reprogramming in killing KRAS‐mutant human lung cancer cells
Kirsten rat sarcoma virus (KRAS) oncogene, found in 20%–25% of lung cancer patients,
potentially regulates metabolic reprogramming and redox status during tumorigenesis …
potentially regulates metabolic reprogramming and redox status during tumorigenesis …
Role of Wnt signaling in the maintenance and regeneration of the intestinal epithelium
The intestinal epithelium plays a key role in digestion and protection against external
pathogens. This tissue presents a high cellular turnover with the epithelium being …
pathogens. This tissue presents a high cellular turnover with the epithelium being …
Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration
H Dushime, SG Moreno, C Linard, A Adrait… - Stem Cell Research & …, 2023 - Springer
Background Human multilineage-differentiating stress enduring (Muse) cells are
nontumorigenic endogenous pluripotent-like stem cells that can be easily obtained from …
nontumorigenic endogenous pluripotent-like stem cells that can be easily obtained from …
Subepithelial Stromal Cells: Their Roles and Interactions with Intestinal Epithelial Cells during Gut Mucosal Homeostasis and Regeneration
Intestinal epithelial cell activities during homeostasis and regeneration are well described,
but their potential interactions with stromal cells remain unresolved. Exploring the functions …
but their potential interactions with stromal cells remain unresolved. Exploring the functions …
Virtual screening–molecular docking–activity evaluation of Ailanthus altissima (Mill.) swingle bark in the treatment of ulcerative colitis
S Ma, L Liu, X Li, Y Xie, X Shi, S Wang - BMC Complementary Medicine …, 2023 - Springer
Background The dried bark of Ailanthus altissima (Mill.) Swingle is widely used in traditional
Chinese medicine for the treatment of ulcerative colitis. The objective of this study was to …
Chinese medicine for the treatment of ulcerative colitis. The objective of this study was to …
RTCB deficiency triggers colitis in mice by influencing the NF-κB and Wnt/β-catenin signaling pathways: RTCB deficiency triggers colitis via NF-κB/Wnt/β-catenin
P Liu, R Zhang, X Song, X Tian, Y Guan… - Acta Biochimica et …, 2024 - pmc.ncbi.nlm.nih.gov
RNA terminal phosphorylase B (RTCB) has been shown to play a significant role in multiple
physiological processes. However, the specific role of RTCB in the mouse colon remains …
physiological processes. However, the specific role of RTCB in the mouse colon remains …
Deep Visual Proteomics advances human colon organoid models by revealing a switch to an in vivo-like phenotype upon xenotransplantation
Intestinal epithelial damage predisposes to chronic disorders like inflammatory bowel
disease. The organoid model allows cultivation, expansion and analysis of primary intestinal …
disease. The organoid model allows cultivation, expansion and analysis of primary intestinal …